Evidence map›Paper›PMID 38918361›Full record

ArticleNature communications2024

Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy.

Ryan R Armbruster, Dushyant Kumar, Blake Benyard, Paul Jacobs, Aditi Khandavilli, Fang Liu, Ravi Prakash Reddy Nanga, Shana McCormack, Anne R Cappola, Neil Wilson and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Effective Modeling of Continuous WaveMagnetic resonance in medicine · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryan R Armbruster *Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0003-0469-8816
Dushyant Kumar *Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Blake BenyardDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Paul JacobsDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0003-3566-4010
Aditi KhandavilliDepartment of Biology, Department of Nutrition and Science, Cornell University, Ithaca, NY, 14850, USA.
Fang LiuDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ravi Prakash Reddy NangaDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Shana McCormackNeuroendocrine Center, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neil WilsonDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ravinder ReddyDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. krr@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-4580-2392

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
NAD+ precursor supplementation with exercise training to improve aerobic capacity in Friedreich's AtaxiaR01HL149722 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MCCORMACK, SHANA ERIN · 2020 to 2024
$4.0M
In vivo Mapping of Muscle Specific MetabolismR01AG071725 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2022 to 2026
$3.1M
Training in Structural, Physiologic and Functional MRIT32EB020087 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI JAMES C GEE, Chamith Sudesh Rajapakse · 2016 to 2026
$2.1M
CrCEST MRI of Skeletal Muscle MetabolismR56AG062665 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2019 to 2019
$656k
Monitoring Oxidative Capacity in Peripheral Artery Disease Patients using MR ImagingR03EB030663 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI KUMAR, DUSHYANT · 2021 to 2022
$163k
NHLBI NIH HHS R01 HL149722NIA NIH HHS R01 AG071725NIA NIH HHS R56 AG062665NIBIB NIH HHS P41 EB029460NIBIB NIH HHS R03 EB030663NIBIB NIH HHS T32 EB020087U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) T32EB020087U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG071725
6 · The paper itself

Abstract

Creatine chemical exchange saturation transfer (CrCEST) MRI is an emerging high resolution and noninvasive method for measuring muscle specific oxidative phosphorylation (OXPHOS). However, CrCEST measurements are sensitive to changes in muscle pH, which might confound the measurement and interpretation of creatine recovery time (τ

Indexed as

Magnetic Resonance ImagingMuscle, SkeletalOxidative PhosphorylationProton Magnetic Resonance SpectroscopyAdultCreatineExerciseFemaleHumansHydrogen-Ion ConcentrationMaleCreatine

Identifiers

PMID38918361
PMCPMC11199598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.