Evidence map›Paper›PMID 38918335›Full record

ArticleFood and environmental virology2024

Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis.

C Veneri, D Brandtner, P Mancini, G Bonanno Ferraro, M Iaconelli, E Suffredini, M Petrillo, G Leoni, V Paracchini, B M Gawlik and 3 more

Abstract read
In one paragraph

Article in Food and environmental virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C VeneriNational Center for Water Safety (CeNSiA), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
D BrandtnerDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
P ManciniNational Center for Water Safety (CeNSiA), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
G Bonanno FerraroNational Center for Water Safety (CeNSiA), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
M IaconelliNational Center for Water Safety (CeNSiA), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
E SuffrediniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
M PetrilloSeidor Italy S.r.l., 20129, Milan, Italy.
G LeoniEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
V ParacchiniEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
B M GawlikEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
A MarchiniEuropean Commission, Joint Research Centre (JRC), Geel, Belgium.
SARI Network
G La RosaNational Center for Water Safety (CeNSiA), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. giuseppina.larosa@iss.it.

Funding

EU funding within the NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases Project no. PE00000007, PE13 INF-ACT
6 · The paper itself

Abstract

The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages, in wastewater samples. By using this assay, we analyzed wastewater samples collected in Italy from September 2023 to January 2024. Our analysis revealed the presence of BA.2.86 lineages already in October 2023 with a minimal detection rate of 2% which then rapidly increased, becoming dominant by January 2024, accounting for a prevalence of 62%. The findings emphasize the significance of wastewater-based surveillance in tracking emerging variants and underscore the efficacy of targeted digital PCR assays for environmental monitoring.

Indexed as

COVID-19SARS-CoV-2WastewaterEnvironmental MonitoringHumansItalyPolymerase Chain ReactionWastewaterBA.2.86Digital PCRJN.1SARS-CoV-2Wastewater surveillance

Identifiers

PMID38918335
PMCPMC11525314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.