Evidence map›Paper›PMID 38918330›Full record

ArticleCEN case reports2025

A case of crystalglobulin-induced nephropathy wherein M protein was identified by mass spectrometry and immunoglobulin G subclass staining.

Hibiki Mochida, Mizuki Kyoda, Yusuke Ushio, Taku Morito, Takahiro Kamiyama, Hideaki Oyagi, Akira Hirasawa, Naoki Hasegawa, Yukio Kakuta, Dedong Kang and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hibiki MochidaDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan. hibiki_mochi@yokohamah.johas.go.jp.
Mizuki KyodaDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan.
Yusuke UshioDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan.
Taku MoritoDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan.
Takahiro KamiyamaDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan.
Hideaki OyagiDepartment of Hematology, Yokohama Rosai Hospital, Yokohama-shi, Kanagawa Prefecture, Japan.
Akira HirasawaDepartment of Hematology, Yokohama Rosai Hospital, Yokohama-shi, Kanagawa Prefecture, Japan.
Naoki HasegawaDepartment of Diagnostic Pathology, Yokohama Rosai Hospital, Yokohama-shi, Kanagawa Prefecture, Japan.
Yukio KakutaDepartment of Diagnostic Pathology, Yokohama Rosai Hospital, Yokohama-shi, Kanagawa Prefecture, Japan.
Dedong KangDepartment of Anatomy Microscopic Anatomy, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.
Kazuho HondaDepartment of Anatomy Microscopic Anatomy, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.
Sekiko TanedaDepartment of Diagnostic Pathology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Michiyasu HatanoDepartment of Nephrology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crystalglobulin-induced nephropathy is a rare disease that causes the deposition of crystallized monoclonal immunoglobulins into the glomerular capillary and arteriole spaces. Here, we report the case of a patient who presented with skin ulcers, urinary protein, and renal dysfunction. The patient underwent renal and skin biopsies, and the biopsy tissue samples were subjected to mass spectrometry. The patient was diagnosed with crystalglobulin-induced nephropathy. A literature review suggested that pathological examinations using electron microscopy, mass spectrometry, and immunofluorescent staining of paraffin-embedded biopsy samples treated with pronase may be useful for the diagnosis of this condition.

Indexed as

Immunoglobulin GMass SpectrometryBiopsyHumansKidneyKidney DiseasesMaleMiddle AgedMyeloma ProteinsSkinImmunoglobulin Gmultiple myeloma M-proteinsMyeloma ProteinsCrystalglobulin-induced nephropathyGlomerulonephritisKidney injuryMass spectrometryMGRS

Identifiers

PMID38918330
PMCPMC11785854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.