Evidence map›Paper›PMID 38918235›Full record

Trial reportNaunyn-Schmiedeberg's archives of pharmacology2024

A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.

Andrea Kuemmerle, Denis Gossen, Michael W Marx, Ulrike Lorch, Maja Szramowska, Ashok Kumar, Dharmendra Singh, Satinder Singh, Hanu Ramachandruni, Byju Thankachen and 4 more

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrea KuemmerleMedicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.
Denis GossenMangareva SRL, Kraainem, Belgium.
Michael W MarxICON Clinical Research Germany GmbH, Langen, Germany.
Ulrike LorchRichmond Pharmacology Ltd, London, UK.
Maja SzramowskaPharmaKinetic Ltd, Quorn, UK.
Ashok KumarIPCA Laboratories Limited, Mumbai, India.
Dharmendra SinghIPCA Laboratories Limited, Mumbai, India.
Satinder SinghIPCA Laboratories Limited, Mumbai, India.
Hanu RamachandruniMedicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.
Byju ThankachenIPCA Laboratories Limited, Mumbai, India.
Swapnil KoreIPCA Laboratories Limited, Mumbai, India.
Myriam El GaaloulMedicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.
Isabelle Borghini-FuhrerMedicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.
Stephan ChalonMedicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland. chalons@mmv.org.ORCID http://orcid.org/0000-0002-9306-1851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atoguanil™ is a novel complex of atovaquone (ATV) and proguanil (PG) with enhanced ATV bioavailability compared to Malarone®. This pilot study assessed whether the relative bioavailability (F

Indexed as

AtovaquoneDrug CombinationsProguanilAdministration, OralAdolescentAdultArea Under CurveBiological AvailabilityCross-Over StudiesFemaleFood-Drug InteractionsHealthy VolunteersHumansMaleMiddle AgedPilot ProjectsAtovaquoneatovaquone, proguanil drug combinationDrug CombinationsProguanilAtovaquone-proguanilBioavailabilityMalariaPharmacokinetics

Identifiers

PMID38918235
PMCPMC11582152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.