ArticleActa neuropathologica2024
Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APP
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Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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Who cites it
9 citing papers in PubMed.
- Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Modeling Alzheimer's disease with brain organoids: mechanisms, applications, and future directions.Frontiers in cell and developmental biology · 2026Review
- Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.Brain communications · 2026Article
- Establishment of molecular subtypes and prognostic models for glioblastoma based on non-apoptotic regulatory cell death genes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Mapping key mitochondrial genes in Alzheimer's disease through human tissue and iPSC derived neurons.Scientific reports · 2025Article
- Review
- Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies.Neuron · 2025Review
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- Review
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Authors and funding
19 authors.
Wenhui QuDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Matti LamDepartment of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.
Julie J McInvaleDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Jason A MaresDepartment of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.
Sam KwonDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Nelson HumalaDepartment of Neurosurgery, Columbia University, New York, NY, USA.
Aayushi MahajanDepartment of Neurosurgery, Columbia University, New York, NY, USA.
Trang NguyenDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Kelly A JakubiakDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Jeong-Yeon MunDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Thomas G TedescoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Osama Al-DalahmahDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Syed A HussainiTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Andrew A SproulDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Markus D SiegelinDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Philip L De JagerDepartment of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.
Peter CanollDepartment of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.
Vilas Menon *Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA. vm2545@cumc.columbia.edu.
Gunnar Hargus *Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA. gh2374@cumc.columbia.edu.ORCID 0000-0001-6487-8857
Funding
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN · 2020 to 2026
$30.1MMedical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3MNeurology Research Education and Mentorship ProgramR25NS070697 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2010 to 2023
$1.9MElucidating the Role of Microglia and Neurotrophin Receptor p75 on Neuronal Degeneration in Frontotemporal DementiaK08NS116166 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HARGUS, GUNNAR · 2021 to 2025
$968kUsing a human stem cell model of tauopathy to evaluate the effects of tau filaments on cell metabolism at a single cell level in vitro and in vivoR21AG070414 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HARGUS, GUNNAR · 2020 to 2020
$446kApplication of single cell sequencing to study astrocyte-mediated neuronal degeneration in a stem cell model of frontotemporal dementiaR03NS112785 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HARGUS, GUNNAR · 2019 to 2020
$162kNIA NIH HHS P30 AG066462NIA NIH HHS P50 AG008702NIA NIH HHS R21 AG070414NIGMS NIH HHS T32 GM145440NINDS NIH HHS K08 NS116166NINDS NIH HHS R03 NS112785NINDS NIH HHS R25 NS070697Thompson Family Foundation GT006988
Abstract
Alzheimer's disease (AD) is the most common cause of dementia, and disease mechanisms are still not fully understood. Here, we explored pathological changes in human induced pluripotent stem cell (iPSC)-derived neurons carrying the familial AD APP
Indexed as
Alzheimer DiseaseAmyloid beta-Protein PrecursorInduced Pluripotent Stem CellsNeuronsTranscriptomeAmyloid beta-PeptidesAnimalsHumansMembrane ProteinsMiceMutationNerve Tissue ProteinsSignal TransductionSynapsesAmyloid beta-PeptidesAmyloid beta-Protein PrecursorMembrane ProteinsNerve Tissue ProteinsAlzheimer’s diseaseDisease modelingGraftsInduced pluripotent stem cellsiPSCsSingle-nucleus RNA sequencingsnRNA-seqTransplantation
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.