ArticleJournal of the American Chemical Society2024
Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically Dispersed
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Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Characterization of Dapalides D and E and Genomic Comparison of the Two Co-Occurring Dapalide-Producing Dapis spp.Journal of natural products · 2026Article
- Tectonic setting shapes microbial biosynthetic potential across global geothermal environments.bioRxiv : the preprint server for biology · 2026Article
- SPECTRE: A Multimodal Spectral Transformer for Small Molecule Annotation.Journal of chemical information and modeling · 2026Article
- Marine natural products.Natural product reports · 2026Review
- Accelerated and Green Synthesis ofJournal of the American Chemical Society · 2026Article
- Respirometry-Based Screening of Marine Natural Products Identifies Leptochelin A as a Novel Modulator of Mitochondrial Function.Oxidative medicine and cellular longevity · 2026Article
- Review
- Molecules to medicine: advances in metabolomics for natural product drug discovery.Current opinion in biotechnology · 2025Review
- Cyanochelin B: a cyanobacterium-produced siderophore with photolytic properties that negate iron monopolization in UV light.Applied and environmental microbiology · 2025Article
- Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in MarineACS chemical biology · 2025Article
- Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling.Nature communications · 2025Article
- Decoding Lusichelins A-E: An In-Depth Look at the Metallophores ofJournal of natural products · 2025Article
- Fatuamide A, a Hybrid PKS/NRPS Metallophore from aJournal of natural products · 2025Article
- Diversity of Cyanobacterial Genera Present in Cabo Verde Marine Environments and the Description ofPlants (Basel, Switzerland) · 2025Article
- Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025Review
- Screening of Lipid-Reducing Activity and Cytotoxicity of the Exometabolome from Cyanobacteria.Marine drugs · 2024Article
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Authors and funding
30 authors.
Nicole E AvalonCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-3588-892X
Mariana A ReisCIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos 4450-208, Portugal.
Christopher C ThornburgCollege of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0002-4657-6895
R Thomas WilliamsonDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0001-7450-3135
Daniel PetrasSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-6561-3022
Allegra T AronSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.
George F NeuhausCollege of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2303-365X
Momen Al-HindyCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Jana MitrevskaCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Leonor FerreiraCIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos 4450-208, Portugal.
João MoraisCIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos 4450-208, Portugal.
Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-4392-7706
Evgenia GlukhovCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Kelsey L AlexanderCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4727-5349
F Alexandra VulpanoviciCollege of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Matthew J BertinCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-2200-0277
Syrena WhitnerCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Hyukjae ChoiCollege of Pharmacy, Yeungnam University, Gyeongsan, Gyeong-buk 38541, South Korea.
Gabriella SpenglerDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged 6725, Hungary.
Kirill BlinovMolecule Apps, LLC, Corvallis, Oregon 97330, United States.
Ameen M AlmohammadiDepartment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
Lamiaa A ShaalaSuez Canal University Hospital, Suez Canal University, Ismailia 41522, Egypt.
William R KewEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, United States.ORCID 0000-0002-4281-4630
Ljiljana Paša-TolićEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, United States.
Diaa T A YoussefDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-3003-1030
Vitor VasconcelosCIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos 4450-208, Portugal.
Lena GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-6108-9000
Kerry L McPhailCollege of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2076-1002
William H GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-1403-4458
Funding
Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1MUnified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2MTraining Program in Marine BiotechnologyT32GM067550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY · 2004 to 2019
$2.0MModulation of Protein Biogenesis and Secretion by Natural Product Translocon LigandsR01GM132649 · NIGMS · OREGON STATE UNIVERSITY · PI ISHMAEL, JANE E, MCPHAIL, KERRY LEIGH · 2019 to 2024
$2.0MCross Repository Metabolomics Data and Workflow IntegrationR03OD034493 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORRESTEIN, PIETER C, WANG, MINGXUN · 2022 to 2022
$303kA Genomic Approach to Discovering Novel Cathepsin Inhibitors from CyanobacteriaF32AT011475 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AVALON, NICOLE ELIZABETH · 2022 to 2024
$218kNCCIH NIH HHS F32 AT011475NCI NIH HHS T32 CA009523NIGMS NIH HHS R01 GM107550NIGMS NIH HHS R01 GM132649NIGMS NIH HHS T32 GM067550NIH HHS R03 OD034493
Abstract
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and the biosynthesis of primary and secondary metabolites. In adaptation to the marine environment, cyanobacteria use metallophores to acquire trace metals when necessary as well as to reduce potential toxicity from excessive metal concentrations. Leptochelins A-C were identified as structurally novel metallophores from three geographically dispersed cyanobacteria of the genus
Indexed as
CyanobacteriaAntineoplastic AgentsCell Line, TumorHumansMultigene FamilyAntineoplastic Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.