Evidence map›Paper›PMID 38918128›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024

The relationship between ischemic penumbra progression and the oxygen content of cortex microcirculation in acute ischemic stroke.

Zhiyuan Shen, Yuxuan Lu, Yingying Ren, Zhaoxia Wang, Jianwen Deng, Ding Nan, Jingjing Jia, Weiwei Yu, Yunyi Jin, Wei Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  2. Review
  3. The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhiyuan ShenDepartment of Neurology, Peking University First Hospital, Beijing 100034, China; Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang 050030, China.
Yuxuan LuDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Yingying RenCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhaoxia WangDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Jianwen DengDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Ding NanDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Jingjing JiaDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Weiwei YuDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Yunyi JinDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Wei SunDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Yining HuangDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Xiaozhong QuCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Haiqiang JinDepartment of Neurology, Peking University First Hospital, Beijing 100034, China. Electronic address: jhq911@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise oxygen content thresholds of ischemic deep parenchymal (OCIDP) and that in cortical microcirculation (OCCM), which leads to ischemic penumbra converting into the infarcted core, remain uncertain. This study employed an invasive fiber-optic oxygen meter and a newly developed oxygen-responsive probe called RuA

Indexed as

Cerebral CortexIschemic StrokeMicrocirculationOxygenAnimalsBrain IschemiaCerebrovascular CirculationDisease ProgressionInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLOxygenAcute ischemic strokeMicrocirculationOxygen contentPenumbra

Identifiers

PMID38918128
PMCPMC11579870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.