Evidence map›Paper›PMID 38918046›Full record

ArticleGenes & development2024

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway.

Allison E Daly, George Yeh, Sofia Soltero, Stephen T Smale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. FPR1-dependent Pro-inflammatory Ccl4Respiratory research · 2025
    Article
  4. Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Examining NF-κB genomic interactions by ChIP-seq and CUT&Tag.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Allison E DalyDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA.
George YehDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA.
Sofia SolteroDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA.
Stephen T SmaleDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA; smale@mednet.ucla.edu.ORCID 0000-0002-9835-6907

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2012 to 2016
$7.8M
Selective Regulation of Pro-Inflammatory Genes in MacrophagesR01GM086372 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALE, STEPHEN T · 2008 to 2015
$2.5M
Selective gene activation by the NF-kappaB family of transcription factorsR01AI073868 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALE, STEPHEN T · 2007 to 2011
$1.8M
Pro-inflammatory gene regulation in a native chromatin environmentR01CA127279 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALE, STEPHEN T · 2008 to 2011
$1.2M
Mechanistically defining the role for each NFkB family member in pro-inflammatory macrophage activationF31AI157267 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DALY, ALLISON E · 2021 to 2022
$78k
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA127279NIAID NIH HHS F31 AI157267NIAID NIH HHS R01 AI073868NIAID NIH HHS T32 AI007323NIAMS NIH HHS P50 AR063020NIGMS NIH HHS R01 GM086372
6 · The paper itself

Abstract

The five NF-κB family members and three nuclear IκB proteins play important biological roles, but the mechanisms by which distinct members of these protein families contribute to selective gene transcription remain poorly understood, especially at a genome-wide scale. Using nascent transcript RNA-seq, we observed considerable overlap between p50-dependent and IκBζ-dependent genes in Toll-like receptor 4 (TLR4)-activated macrophages. Key immunoregulatory genes, including

Indexed as

Gene Expression RegulationMacrophagesNF-kappa B p50 SubunitSignal TransductionToll-Like Receptor 4Adaptor Proteins, Signal TransducingAnimalsI-kappa B ProteinsInflammationMaleMiceProtein BindingTranscription Factor RelAAdaptor Proteins, Signal TransducingI-kappa B ProteinsNF-kappa B p50 SubunitNfkb1 protein, mouseNfkbiz protein, mouseToll-Like Receptor 4Transcription Factor RelAinflammationinnate immunityIκBζmacrophagesNF-κBtranscription

Identifiers

PMID38918046
PMCPMC11293394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.