Evidence map›Paper›PMID 38917860›Full record

ArticleAsian spine journal2024

Correlation between the maximum standard uptake value and mean Hounsfield unit on single-photon emission computed tomography-computed tomography to discriminate benign and metastatic lesions among patients with breast cancer.

S Thadchaiani Saminathan, Wan Aireene Wan Ahmed, Norazlina Mat Nawi, Nashrulhaq Tagiling, Ilyana Aziz, Yusri Udin, Mohd Fazrin Mohd Rohani, Wan Mohd Nazlee Wan Zainon, Mohammad Khairul Azhar Abdul Razab

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Article in Asian spine journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

S Thadchaiani SaminathanDepartment of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Wan Aireene Wan AhmedDepartment of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Norazlina Mat NawiDepartment of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Nashrulhaq TagilingDepartment of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Ilyana AzizDepartment of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Yusri UdinDepartment of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Mohd Fazrin Mohd RohaniDepartment of Nuclear Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Wan Mohd Nazlee Wan ZainonDepartment of Family Medicine, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia.
Mohammad Khairul Azhar Abdul RazabMedical Radiation Program, School of Health Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.

Funding

Fundamental Research Grant Scheme, Ministry of Higher Education FRGS/1/2020/ SKK08/USM/02/1Universiti Sains Malaysia 304/PPSG/631534
6 · The paper itself

Abstract

STUDY

designRetrospective study. PURPOSE: To compare and correlate technetium-99m methylene diphosphonate uptake between benign and metastatic bone lesions using semiquantitative analysis of maximum standard uptake value (SUVmax) and mean Hounsfield unit (HU) in single-photon emission computed tomography-computed tomography (SPECT-CT). OVERVIEW OF LITERATURE: Qualitative interpretation of metastatic bone lesions in breast cancer on bone scintigraphy is often complicated by coexisting benign lesions.

methodsIn total, 185 lesions were identified on bone and SPECT-CT scans from 32 patients. Lesions were classified as metastatic (109 sclerotic lesions) and benign (76 lesions) morphologically on low-dose CT. Semiquantitative analysis using SUVmax and mean HU was performed on the lesions and compared. To discriminate benign and metastatic lesions, the correlation between SUVmax and mean HU was determined using the intraclass correlation coefficients.

resultsThe SUVmax was higher in metastatic lesions (20.66±14.36) but lower in benign lesions (10.18±12.79) (p<0.001). The mean HU was lower in metastatic lesions (166.62±202.02) but higher in benign lesions (517.65±192.8) (p<0.001). A weak negative correlation was found between the SUVmax and the mean HU for benign lesions, and a weak positive correlation was noted between the SUVmax and the mean HU on malignant lesions with no statistical significance (p=0.394 and 0.312, respectively). The cutoff values obtained were 10.8 for SUVmax (82.6% sensitivity and 84.2% specificity) and 240.86 for the mean HU (98.7% sensitivity and 88.1% specificity) in differentiating benign from malignant bone lesions.

conclusionsSemiquantitative assessment using SUVmax and HU can complement qualitative analysis. Metastatic lesions had higher SUVmax but lower mean HU than benign lesions, whereas benign lesions demonstrated higher mean HU but lower SUVmax. A weak correlation was found between the SUVmax and the mean HU on malignant and benign lesions. Cutoff values of 10.8 for the SUVmax and 240.86 for the mean HU may differentiate bone metastases from benign lesions.

Indexed as

Bone metastasisBreast neoplasmsHounsfield unitSingle-photon emission computed tomographyStandardized uptake value maximum

Identifiers

PMID38917860
PMCPMC11222895

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