Evidence map›Paper›PMID 38917821›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Isolation and Growth Kinetics of Bogoria Virus from Phlebotomine Sandflies Sampled in Baringo, Kenya.

Jane Wambui Thiiru, Solomon Langat, Francis Mulwa, Stephanie Cinkovich, Hellen Koka, Santos Yalwala, Samoel Khamadi, Justus Onguso, Nicholas Odemba, Francis Ngere and 5 more

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jane Wambui ThiiruDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Solomon LangatCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Francis MulwaCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Stephanie CinkovichGlobal Emerging Infections Surveillance Branch, U.S. Armed Forces Health Surveillance Division, Silver Spring, Maryland.
Hellen KokaCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Santos YalwalaDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Samoel KhamadiCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Justus OngusoInstitute for Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Nicholas OdembaDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Francis NgereDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Jaree JohnsonU.S. Armed Forces Pest Management Board, Silver Spring, Maryland.
Timothy EgboDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Eric GargesDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Elly OjwangDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Fredrick EyaseDepartment of Emerging Infectious Diseases, U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phleboviruses are an emerging threat to public health. Recent surveillance efforts in Kenya have unveiled novel phleboviruses. Despite these efforts, there remain knowledge gaps. This study tested female sandflies from diverse ecological settings in Kenya for arboviruses. Sandfly pools were cultured in Vero-CCL cells. Pools showing reproducible cytopathic effects were subjected to next-generation sequencing, followed by phylogenetic analysis. In vitro, cell kinetics analysis was performed using both Vero-E6 cells and C6/36 mosquito cells. One pool from Baringo, Kenya, tested positive for Bogoria virus (BOGV). The BOGV genome clustered in a single clade with previously obtained BOGV genomes. No significant differences were observed between Vero and C6/36 cell growth kinetics. This study has confirmed the presence of BOGV among sandflies in Baringo Kenya and demonstrated growth in mosquito cells.

Indexed as

PsychodidaeAnimalsCell LineChlorocebus aethiopsFemaleGenome, ViralInsect VectorsKenyaKineticsPhlebovirusPhylogenyVero Cells

Identifiers

PMID38917821
PMCPMC11310608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.