Evidence map›Paper›PMID 38917802›Full record

ArticleCell reports. Medicine2024

Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy.

Marie Deffner, Tilman Schneider-Hohendorf, Andreas Schulte-Mecklenbeck, Simon Falk, I-Na Lu, Patrick Ostkamp, Louisa Müller-Miny, Eva Maria Schumann, Susan Goelz, Ellen Cahir-McFarland and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Digital signatures of fatigue and wearing-off symptoms in patients with multiple sclerosis under natalizumab.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Article
  3. Article
  4. Observational
  5. Spatially segregated APOETheranostics · 2025
    Article
  6. CD4Frontiers in immunology · 2025
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marie DeffnerDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Tilman Schneider-HohendorfDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Andreas Schulte-MecklenbeckDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Simon FalkDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
I-Na LuDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Patrick OstkampDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Louisa Müller-MinyDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Eva Maria SchumannDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Susan GoelzOregon Health & Science University, Portland, OR, USA; Biogen, Cambridge, MA, USA.
Ellen Cahir-McFarlandBiogen, Cambridge, MA, USA; Abata Therapeutics, Cambridge, MA, USA.
Kiran T ThakurDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Luisa KlotzDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Gerd Meyer Zu HörsteDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Catharina C GrossDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Oliver M GrauerDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Nicholas SchwabDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. Electronic address: nicholas.schwab@ukmuenster.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) has been associated with different forms of immune compromise. This study analyzes the chemokine signals and attracted immune cells in cerebrospinal fluid (CSF) during PML to define immune cell subpopulations relevant for the PML immune response. In addition to chemokines that indicate a general state of inflammation, like CCL5 and CXCL10, the CSF of PML patients specifically contains CCL2 and CCL4. Single-cell transcriptomics of CSF cells suggests an enrichment of distinct CD4

Indexed as

Cell MovementCentral Nervous SystemChemokinesLeukoencephalopathy, Progressive MultifocalAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansMaleMiddle AgedChemokinescentral nervous systemcerebrospinal fluidchemokinesHIVimmune cell migrationmultiple sclerosisnatalizumabprogressive multifocal leukoencephalopathysingle-cell RNA sequencingviral encephalitis

Identifiers

PMID38917802
PMCPMC11293326

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.