Evidence map›Paper›PMID 38917176›Full record

ArticlePloS one2024

Pan-cancer analysis of PSCA that is associated with immune infiltration and affects patient prognosis.

Chenxing Wang, Xingjia Zhu, Ming Zheng, Yixun Chen, Rui Jiang, Xinyi He, Zongheng Liu, Zhichao Lu, Ziheng Wang, Yang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenxing WangDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Medical school of Nantong University, Nantong, China.
Xingjia ZhuDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Medical school of Nantong University, Nantong, China.
Ming ZhengResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Yixun ChenEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Rui JiangDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Medical school of Nantong University, Nantong, China.
Xinyi HeDepartment of Clinical Biobank & Institute of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Zongheng LiuDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Medical school of Nantong University, Nantong, China.
Zhichao LuDepartment of Neurosurgery, Affiliated Hospital of Nantong University, Medical school of Nantong University, Nantong, China.
Ziheng WangDepartment of Clinical Biobank & Institute of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.ORCID 0000-0001-8873-732X
Yang YangDepartment of Trauma Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.ORCID 0000-0003-1222-1209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate stem cell antigen (PSCA) is associated with disease progression, promotion of angiogenesis, invasion, metastasis and immune evasion in cancer. However, its expression pattern and diagnostic and prognostic potential have not been thoroughly analysed from a pan-cancer perspective. This study aimed to examine the effects of PSCA on the prognosis and inflammatory cell infiltration patterns of various cancer types. We analysed the relationship between PSCA expression and immunological subtypes in tumor microenvironment (TME) and the role of molecular subtypes, potentially promising immune biomarkers and tumour-infiltrating lymphocytes (TILs) in various cancer types, especially lung adenocarcinoma (LUAD). In addition, we investigated the prognostic significance of PSCA expression in LUAD. The co-expression network of PSCA was found to be mainly involved in the regulation of immune responses and antigen processing and expression and was significantly enriched in pathological and substance metabolism-related pathways in cancer. Altogether, this study reveals that PSCA is a promising target for immunotherapy in patients with cancer.

Indexed as

Antigens, NeoplasmGPI-Linked ProteinsLymphocytes, Tumor-InfiltratingNeoplasm ProteinsTumor MicroenvironmentAdenocarcinoma of LungBiomarkers, TumorGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleNeoplasmsPrognosisAntigens, NeoplasmBiomarkers, TumorGPI-Linked ProteinsNeoplasm ProteinsPSCA protein, human

Identifiers

PMID38917176
PMCPMC11198779

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