Evidence map›Paper›PMID 38916922›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2024

TrajVis: a visual clinical decision support system to translate artificial intelligence trajectory models in the precision management of chronic kidney disease.

Zuotian Li, Xiang Liu, Ziyang Tang, Nanxin Jin, Pengyue Zhang, Michael T Eadon, Qianqian Song, Yingjie V Chen, Jing Su

Abstract readValidation Study
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  12. Reflections on interactive visualization of electronic health records: past, present, future.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zuotian LiDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, United States.ORCID 0000-0002-8317-2873
Xiang LiuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Ziyang TangDepartment of Computer and Information Technology, Purdue University, West Lafayette, IN 47907, United States.
Nanxin JinDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Pengyue ZhangDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Michael T EadonDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States.ORCID 0000-0003-3066-2876
Qianqian SongDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL 32610, United States.ORCID 0000-0002-4455-5302
Yingjie V ChenDepartment of Computer Graphics Technology, Purdue University, West Lafayette, IN 47907, United States.
Jing SuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, United States.ORCID 0000-0003-4917-6173

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Revealing Health Trajectories of Chronic Kidney Disease for Precision MedicineR01LM013771 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI SU, JING, ZHANG, PENGYUE · 2022 to 2025
$1.7M
Multi-modal insights of spatially distributed cells with associations of diseases and drug responseR35GM151089 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Qianqian Song · 2023 to 2026
$1.2M
Indiana University Precision Health InitiativeNational Institute of Health R01LM013771NCI NIH HHS P30 CA082709NCI NIH HHS P30CA 082709NIGMS NIH HHS R35 GM151089NIGMS NIH HHS R35GM151089NLM NIH HHS R01 LM013771
6 · The paper itself

Abstract

objectiveOur objective is to develop and validate TrajVis, an interactive tool that assists clinicians in using artificial intelligence (AI) models to leverage patients' longitudinal electronic medical records (EMRs) for personalized precision management of chronic disease progression. MATERIALS AND

methodsWe first perform requirement analysis with clinicians and data scientists to determine the visual analytics tasks of the TrajVis system as well as its design and functionalities. A graph AI model for chronic kidney disease (CKD) trajectory inference named DisEase PrOgression Trajectory (DEPOT) is used for system development and demonstration. TrajVis is implemented as a full-stack web application with synthetic EMR data derived from the Atrium Health Wake Forest Baptist Translational Data Warehouse and the Indiana Network for Patient Care research database. A case study with a nephrologist and a user experience survey of clinicians and data scientists are conducted to evaluate the TrajVis system.

resultsThe TrajVis clinical information system is composed of 4 panels: the Patient View for demographic and clinical information, the Trajectory View to visualize the DEPOT-derived CKD trajectories in latent space, the Clinical Indicator View to elucidate longitudinal patterns of clinical features and interpret DEPOT predictions, and the Analysis View to demonstrate personal CKD progression trajectories. System evaluations suggest that TrajVis supports clinicians in summarizing clinical data, identifying individualized risk predictors, and visualizing patient disease progression trajectories, overcoming the barriers of AI implementation in healthcare. DISCUSSION: The TrajVis system provides a novel visualization solution which is complimentary to other risk estimators such as the Kidney Failure Risk Equations.

conclusionTrajVis bridges the gap between the fast-growing AI/ML modeling and the clinical use of such models for personalized and precision management of chronic diseases.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalDisease ProgressionElectronic Health RecordsRenal Insufficiency, ChronicHumansPrecision MedicineUser-Computer Interfacedisease trajectoryelectronic medical recordsgraph artificial intelligencevisual analytics

Identifiers

PMID38916922
PMCPMC11491615

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.