Evidence map›Paper›PMID 38916845›Full record

ReviewCardiovascular toxicology2024

Oxidative and Nitrous Stress Underlies Vascular Malfunction Induced by Ionizing Radiation and Diabetes.

Anatoly Soloviev, Vadym Sydorenko

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anatoly SolovievDepartment for Pharmacology of Cellular Signaling Systems and Experimental Therapeutics, Institute of Pharmacology and Toxicology, National Academy of Medical Science, Kyiv, Ukraine. tonysolpharm@gmail.com.
Vadym SydorenkoDepartment for Pharmacology of Cellular Signaling Systems and Experimental Therapeutics, Institute of Pharmacology and Toxicology, National Academy of Medical Science, Kyiv, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress results from the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in quantities exceeding the potential activity of the body's antioxidant system and is one of the risk factors for the development of vascular dysfunction in diabetes and exposure to ionizing radiation. Being the secondary products of normal aerobic metabolism in living organisms, ROS and RNS act as signaling molecules that play an important role in the regulation of vital organism functions. Meanwhile, in high concentrations, these compounds are toxic and disrupt various metabolic pathways. The various stress factors (hyperglycemia, gamma-irradiation, etc.) trigger free oxygen and nitrogen radicals accumulation in cells that are capable to damage almost all cellular components including ion channels and transporters such as Na

Indexed as

Oxidative StressReactive Oxygen SpeciesAnimalsDiabetes MellitusDiabetic AngiopathiesHumansNitrosative StressRadiation InjuriesRadiation, IonizingReactive Nitrogen SpeciesSignal TransductionReactive Nitrogen SpeciesReactive Oxygen SpeciesBKCa channelsC-kinase activityDiabetesHypertensionIonized irradiationReactive oxygen and nitrogen speciesTRP channels

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.