Evidence map›Paper›PMID 38916824›Full record

SynthesisSports medicine (Auckland, N.Z.)2024

The Best Exercise Modality and Dose to Reduce Glycosylated Hemoglobin in Patients with Type 2 Diabetes: A Systematic Review with Pairwise, Network, and Dose-Response Meta-Analyses.

Zhide Liang, Meng Zhang, Chuanzhi Wang, Fengwei Hao, Yingdanni Yu, Shudong Tian, Yang Yuan

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhide LiangSchool of Sports Science, Qufu Normal University, Qufu, 273165, China.
Meng ZhangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
Chuanzhi WangSchool of Physical Education and Sports Exercise, South China Normal University, Guangzhou, 510006, China.
Fengwei HaoSchool of Physical Education and Sports Exercise, South China Normal University, Guangzhou, 510006, China.
Yingdanni YuSchool of Physical Education, Shandong University, Jinan, 250061, China.
Shudong TianSchool of Physical Education, Shandong University, Jinan, 250061, China. 202220807@mail.sdu.edu.cn.
Yang YuanSchool of Sports Science, Qufu Normal University, Qufu, 273165, China. yuanyangofficial@yeah.net.ORCID 0000-0002-5552-4958

Funding

National Natural Science Foundation of China 32000830Taishan Scholars tsqn202312181
6 · The paper itself

Abstract

backgroundPersistently elevated glycosylated hemoglobin (HbA1c) is associated with a higher risk of long-term vascular complications.

objectiveWe evaluated the effect of different exercise modalities and doses on HbA1c levels in patients with type 2 diabetes.

methodsA systematic search for randomized controlled trials involving exercise interventions in patients with type 2 diabetes was conducted across seven electronic databases, encompassing data from their inception up to October 2023. Two independent reviewers assessed the quality of the literature. Pairwise, network, and dose-response meta-analyses using the random-effects model were conducted to analyze the effect of exercise on HbA1c levels.

resultsA total of 85 randomized controlled trials with 5535 participants were included. The network meta-analysis showed that high-intensity interval training (HIIT) has the highest ranked (MD =  - 0.78% [- 8.50 mmol/mol]; 95% CrI:  - 1.04, - 0.51), followed by combined aerobic and resistance exercise (CE) (MD =  - 0.54% [- 5.90 mmol/mol]; 95% CrI: - 0.69, - 0.40), yoga (MD =  - 0.45% [- 4.92 mmol/mol]; 95% CrI: - 0.77, - 0.13), and continuous aerobic exercise (CAE) (MD =  - 0.42% [- 4.58 mmol/mol]; 95% CrI: - 0.54, - 0.30). In addition, a significant improvement in HbA1c levels can be observed when the total exercise dose reaches 840 metabolic equivalent of tasks-min/week.

conclusionsThere was low-quality evidence that HIIT, CE, yoga, and CAE may be effective treatment modalities for improving HbA1c in patients with type 2 diabetes, and there was no significant difference in efficacy. Moreover, a non-linear dose-response relationship was found for total exercise and HbA1c levels. Future research should further investigate the specific effects of different exercise doses on HbA1c levels in patients with type 2 diabetes and provide a more personalized exercise prescription.

Indexed as

Diabetes Mellitus, Type 2Exercise TherapyGlycated HemoglobinHigh-Intensity Interval TrainingHumansRandomized Controlled Trials as TopicResistance TrainingYogaGlycated Hemoglobin

Identifiers

PMID38916824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.