Evidence map›Paper›PMID 38916728›Full record

Observational studyAging and disease2024

Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects.

Ting Shen, Samran Sheriff, Yuyi You, Jiyang Jiang, Angela Schulz, Heather Francis, Mehdi Mirzaei, Danit Saks, Viswanthram Palanivel, Devaraj Basavarajappa and 8 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ting ShenDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.
Samran SheriffMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Yuyi YouMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Jiyang JiangCentre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Angela SchulzMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Heather FrancisMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Mehdi MirzaeiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Danit SaksMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Viswanthram PalanivelMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Devaraj BasavarajappaMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Nitin ChitranshiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Veer GuptaFaculty of Health, Deakin University, VIC 3125, Australia.
Wei WenCentre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Huixun JiaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.
Xiaodong SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.
Stuart L GrahamMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Vivek K GuptaMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with progressive brain atrophy and declines in learning and memory, often attributed to hippocampal or cortical deterioration. The role of brain-derived neurotrophic factor (BDNF) in modulating the structural and functional changes in the brain and visual system, particularly in relation to BDNF Val66Met polymorphism, remains underexplored. In this present cross-sectional observational study, we aimed to assess the effects of BDNF polymorphism on brain structural integrity, cognitive function, and visual pathway alterations. A total of 108 older individuals with no evidence of dementia and a mean (SD) age of 67.3 (9.1) years were recruited from the Optic Nerve Decline and Cognitive Change (ONDCC) study cohort. The BDNF Met allele carriage had a significant association with lower entorhinal cortex volume (6.7% lower compared to the Val/Val genotype, P = 0.02) and posterior cingulate volume (3.2% lower than the Val/Val group, P = 0.03), after adjusting for confounding factors including age, sex and estimated total intracranial volumes (eTIV). No significant associations were identified between the BDNF Val66Met genotype and other brain volumetric or diffusion measures, cognitive performances, or vision parameters except for temporal retinal nerve fibre layer thickness. Small but significant correlations were found between visual structural and functional, cognitive, and brain morphological metrics. Our findings suggest that carriage of BDNF Val66Met polymorphism is associated with lower entorhinal cortex and posterior cingulate volumes and may be involved in modulating the cortical morphology along the aging process.

Indexed as

Brain-Derived Neurotrophic FactorAgedCerebral CortexCognitionCross-Sectional StudiesFemaleGenotypeHealthy AgingHumansMagnetic Resonance ImagingMaleMiddle AgedPolymorphism, Single NucleotideBDNF protein, humanBrain-Derived Neurotrophic Factor

Identifiers

PMID38916728
PMCPMC11346411

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.