Evidence map›Paper›PMID 38916640›Full record

ArticlePsychopharmacology2024

5-hydroxytryptamine 2C/1A receptors modulate the biphasic dose response of the head twitch response and locomotor activity induced by DOM in mice.

Huili Zhu, Longyu Wang, Xiaoxuan Wang, Yishan Yao, Peilan Zhou, Ruibin Su

Abstract read
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In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Integrated 5-HTMolecular psychiatry · 2026
    Article
  2. Article
  3. Article
  4. Serotonin 5-HTACS chemical neuroscience · 2025
    Article
  5. Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice.The international journal of neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huili Zhu *State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China.
Longyu Wang *State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China.
Xiaoxuan WangState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China.
Yishan YaoState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China.
Peilan ZhouState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China. zhoupeilan0502@sina.com.
Ruibin SuState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China. ruibinsu@126.com.

Funding

National Natural Science Foundation of China No. 82273909
6 · The paper itself

Abstract

rationaleThe phenylalkylamine hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM) exhibits an inverted U-shaped dose-response curve for both head twitch response (HTR) and locomotor activity in mice. Accumulated studies suggest that HTR and locomotor hyperactivity induced by DOM are mainly caused by the activation of serotonin 5-hydroxytryptamine 2 A receptor (5-HT

objectivesThe primary objective of this study is to investigate the modulation of 5-HT

methodsIn this study, we employed pharmacological methods to identify the specific 5-HT receptor subtypes responsible for mediating the biphasic dose-response effects of DOM on HTR and locomotor activity in C57BL/6J mice.

resultsThe 5-HT

conclusionsReceptor subtypes 5-HT

Indexed as

Dose-Response Relationship, DrugReceptor, Serotonin, 5-HT2CAminopyridinesAnimalsDOM 2,5-Dimethoxy-4-MethylamphetamineFluorobenzenesHallucinogensHead MovementsIndolesLocomotionMaleMiceMice, Inbred C57BLMotor ActivityPiperidinesReceptor, Serotonin, 5-HT1A5-hydroxytryptamine2C receptor, mouse6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineAminopyridinesDOM 2,5-Dimethoxy-4-MethylamphetamineFluorobenzenesHallucinogensHtr1a protein, mouseIndolesPiperidinesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor Antagonistsvolinanserin5-HT2A receptor 5-HT2C receptor 5-HT1A receptor head twitch response locomotor activity DOM

Identifiers

PMID38916640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.