Evidence map›Paper›PMID 38916635›Full record

ArticleJournal of materials science. Materials in medicine2024

Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes.

Mingming Cai, Wangdu Luo, Kevin Feng, Yi Chen, Lin Yi, Xiaomin Zhu, Ju He, Hong Liu, Cindy Hutnik, Yong Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingming CaiDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Wangdu LuoDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Kevin FengDepartment of Basic Medical Science, Western University, London, ON, Canada.
Yi ChenSchool of Materials Science and Engineering, National Engineering and Technology Research Center for Magnesium Alloy Materials, Chongqing University, Chongqing, 400045, China.
Lin YiDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Xiaomin ZhuDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Ju HeDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Hong LiuDepartment of Ophthalmology, Ivey Eye Institute, St. Joseph's Health Care London, Western University, London, ON, Canada.
Cindy HutnikDepartment of Ophthalmology, Ivey Eye Institute, St. Joseph's Health Care London, Western University, London, ON, Canada.
Yong WangSchool of Materials Science and Engineering, National Engineering and Technology Research Center for Magnesium Alloy Materials, Chongqing University, Chongqing, 400045, China.
Xiangji LiDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. lixiangji@hospital.cqmu.edu.cn.
Lin XieDepartment of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. xielin@hospital.cqmu.edu.cn.

Funding

the Natural Science Foundation of Chongqing Grant No. csts2018jcyjAX0016
6 · The paper itself

Abstract

The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly leading to surgical failure. We developed a biodegradable material hydroxyapatite-coated magnesium (HA-Mg) as a glaucoma drainage device. Twelve New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (6 right eyes), trabeculectomy group (6 right eyes), and control group (12 left eyes). Results showed that all HA-Mg drainage plates were completely degraded ~4 months postoperatively. At the 5th month postoperatively, there was no statistical difference in the corneal endothelium density between the HA-Mg drainage plate group and the control group (p = 0.857). The intraocular pressure (IOP) level in the HA-Mg drainage plate implantation group was lower than in the other two groups. The trypan blue dye still drained from the anterior chamber to the subconjunctiva 5 months after HA-Mg drainage plate implantation. HE staining revealed the scleral linear aqueous humor drainage channel and anterior synechia were observed after drainage plate completely degraded, with no obvious infiltration with the inflammatory cells. This study showed the safety and efficacy of HA-Mg glaucoma drainage plate in controlling IOP after implantation into the anterior chamber of rabbit eyes.

Indexed as

Anterior ChamberGlaucomaGlaucoma Drainage ImplantsIntraocular PressureMagnesiumAnimalsDurapatiteRabbitsTrabeculectomyDurapatiteMagnesium

Identifiers

PMID38916635
PMCPMC11199312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.