Evidence map›Paper›PMID 38915927›Full record

ArticleBrain communications2024

Brain lesions causing parkinsonism versus seizures map to opposite brain networks.

Frederic L W V J Schaper, Mae Morton-Dutton, Niels Pacheco-Barrios, Joseph I Turner, William Drew, Sanaz Khosravani, Juho Joutsa, Michael D Fox

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. An MRI Atlas of Regional Brain Vulnerability to Metastatic Disease.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Frederic L W V J SchaperCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-5487-0923
Mae Morton-DuttonCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Niels Pacheco-BarriosCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Joseph I TurnerCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
William DrewCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sanaz KhosravaniCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Juho JoutsaTurku Brain and Mind Center, Clinical Neurosciences, University of Turku, 20520 Turku, Finland.ORCID https://orcid.org/0000-0002-3457-9415
Michael D FoxCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-8848-6399

Funding

Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
Identifying neuromodulation targets for pain in the human brainR21NS123813 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2022 to 2023
$492k
NINDS NIH HHS R01 NS127892NINDS NIH HHS R21 NS123813
6 · The paper itself

Abstract

Recent epidemiological studies propose an association between parkinsonism and seizures, but the direction of this association is unclear. Focal brain lesions causing new-onset parkinsonism versus seizures may provide a unique perspective on the causal relationship between the two symptoms and involved brain networks. We studied lesions causing parkinsonism versus lesions causing seizures and used the human connectome to identify their connected brain networks. Brain networks for parkinsonism and seizures were compared using spatial correlations on a group and individual lesion level. Lesions not associated with either symptom were used as controls. Lesion locations from 29 patients with parkinsonism were connected to a brain network with the opposite spatial topography (spatial

Indexed as

epilepsyhuman connectomelesion network mappingParkinson’s disease

Identifiers

PMID38915927
PMCPMC11195636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.