ArticleFrontiers in chemistry2024
Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma.
Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Nanozyme for precision treatment of hepatocellular carcinoma.Materials today. Bio · 2026Review
- Effect of Dietary Supplementation with Methyl Salicylate on Performance, Blood Biochemistry, Intestinal Morphology, and Meat Quality of White-Feather Broilers.The journal of poultry science · 2026Article
- Article
- Galangin-loaded chitosan nanoparticles inhibit the cell cycle progression and cell proliferation by modulating cyclin-dependent kinases in breast cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Numerous local herbal extract species have been investigated as potential medicinal ingredients due to their promising anti-cancer properties. However, the primary constraint of the class of plant flavonoids lies in their low solubility and limited membrane permeability, leading to chemical instability and restricted bioavailability that impede biomedical applications. In this study, we have developed an ideal nanozyme-Galazyme, comprising galangin-loaded copper Nanozyme coated by DSPE-PEG, which amplifies oxidative stress to induce apoptosis via the regulation of reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) activation. Galazyme exhibited significant peroxidase mimetic activity, demonstrating its potential to generate ROS and elevate oxidative stress. Upon uptake by HepG-2 cells, Galazyme efficiently converts excess hydrogen peroxide (H2O2) into highly reactive •OH radicals and upregulates MAPK expression, leading to the activation of Bax and Caspase 3, thereby promoting irreversible tumor cell apoptosis. Both
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