Evidence map›Paper›PMID 38915776›Full record

SynthesisFrontiers in physiology2024

Systematic review: pain, cognition, and cardioprotection-unpacking oxytocin's contributions in a sport context.

Péter Szabó, Sara Bonet, Roland Hetényi, Dániel Hanna, Zsófia Kovács, Gyöngyvér Prisztóka, Zuzana Križalkovičová, József Szentpéteri

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Péter SzabóFaculty of Sciences, Institute of Sports Science and Physical Education, University of Pécs, Pécs, Hungary.
Sara BonetFaculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Roland HetényiRoLink Biotechnology Kft., Pécs, Hungary.
Dániel HannaRoLink Biotechnology Kft., Pécs, Hungary.
Zsófia KovácsFaculty of Sciences, Institute of Sports Science and Physical Education, University of Pécs, Pécs, Hungary.
Gyöngyvér PrisztókaFaculty of Sciences, Institute of Sports Science and Physical Education, University of Pécs, Pécs, Hungary.
Zuzana KrižalkovičováFaculty of Health Sciences, Institute of Physiotherapy and Sport Science, Department of Sport Science, Pécs, Hungary.
József SzentpéteriMedical School, Institute of Transdisciplinary Discoveries, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This systematic review investigates the interplay between oxytocin and exercise; in terms of analgesic, anti-inflammatory, pro-regenerative, and cardioprotective effects. Furthermore, by analyzing measurement methods, we aim to improve measurement validity and reliability. Methods: Utilizing PRISMA, GRADE, and MECIR protocols, we examined five databases with a modified SPIDER search. Including studies on healthy participants, published within the last 20 years, based on keywords "oxytocin," "exercise" and "measurement," 690 studies were retrieved initially (455 unique records). After excluding studies of clinically identifiable diseases, and unpublished and reproduction-focused studies, 175 studies qualified for the narrative cross-thematic and structural analysis. Results: The analysis resulted in five categories showing the reciprocal impact of oxytocin and exercise: Exercise (50), Physiology (63), Environment (27), Social Context (65), and Stress (49). Exercise-induced oxytocin could promote tissue regeneration, with 32 studies showing its analgesic and anti-inflammatory effects, while 14 studies discussed memory and cognition. Furthermore, empathy-associated Discussion: Oxytocin's effect on fear extinction and social cognition might generate strategies for mental training, and technical, and tactical development in sports. Exercise-induced oxytocin can affect the amount of stress experienced by athletes, and their response to it. However, oxytocin levels could depend on the type of sport in means of contact level, exercise intensity, and duration. The influence of oxytocin on athletes' performance and recovery could have been exploited due to its short half-life. Examining oxytocin's complex interactions with exercise paves the way for future research and application in sports science, psychology, and medical disciplines. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=512184, identifier CRD42024512184.

Indexed as

cardioprotectioncognitionexercisemeasurementoxytocinpain

Identifiers

PMID38915776
PMCPMC11194439

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.