Evidence map›Paper›PMID 38915659›Full record

ArticlebioRxiv : the preprint server for biology2025

Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.

Dominic W H Shayler, Kevin Stachelek, Linda Cambier, Sunhye Lee, Jinlun Bai, Bhavana Bhat, Mark W Reid, Daniel J Weisenberger, Jennifer G Aparicio, Yeha Kim and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Dominic W H ShaylerThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1971-2617
Kevin StachelekThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Linda CambierThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Sunhye LeeThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jinlun BaiThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Bhavana BhatThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Mark W ReidThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Daniel J WeisenbergerDepartment of Cancer Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jennifer G AparicioThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Yeha KimThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Mitali SinghThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Maxwell BayDevelopment, Stem Cell, and Regenerative Medicine Program, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Matthew E ThorntonMaternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eamon K DoyleDepartment of Radiology and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Zachary FouladianThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Stephan G ErberichDepartment of Radiology and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Brendan H GrubbsMaternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael A BonaguidiDepartment of Development, Stem Cell, and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9295-4762
Cheryl Mae CraftDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hardeep P SinghThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
David CobrinikThe Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4478-2417

Funding

Successive responses to oncogenic aberrations in retinoblastoma genesis.R01CA137124 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI David Cobrinik · 2011 to 2026
$6.3M
Neural stem cell rejuvenation through single cell pharmacogenomicsR01AG076956 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MICHAEL Bonaguidi · 2022 to 2026
$3.9M
Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
Human Specific Signaling Circuitry in Cone Precursor DevelopmentR01EY026661 · NEI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COBRINIK, DAVID · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA137124NEI NIH HHS R01 EY026661NIA NIH HHS R01 AG076956NICHD NIH HHS T32 HD060549
6 · The paper itself

Abstract

Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq) to distinguish post-mitotic cone and rod developmental states and identify cone-specific features that contribute to retinoblastomagenesis. The analyses revealed nascent, immediately post-mitotic cone- and rod precursor populations characterized by higher THRB or NRL regulon activities, immature and maturing cone and rod precursors with concurrent cone- and rod-related gene and regulon expression, and distinct early and late cone and rod maturation states distinguished by maturation-associated declines in RAX regulon activity. Cell-state-specific gene expression features inferred based on full-length scRNA-seq were consistent with past single nucleus 3' RNA-seq analyses. Beyond the cell state characterizations, full-length scRNAseq revealed that both L/M cone and rod precursors co-expressed

Identifiers

PMID38915659
PMCPMC11195049

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.