Evidence map›Paper›PMID 38915644›Full record

ArticlebioRxiv : the preprint server for biology2026

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.

Prasanna Katti, Praveena Prasad, Sepiso K Masenga, Prasanna Venkhatesh, Zer Vue, Andrea G Marshall, Benjamin Rodriguez, Han Le, Edgar Garza-Lopez, Alexandria Murphy and 37 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

47 authors.

Prasanna KattiDepartment of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.
Praveena PrasadDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801.
Sepiso K MasengaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0000-0003-4376-5831
Prasanna VenkhateshDepartment of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Benjamin RodriguezDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Han LeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Edgar Garza-LopezDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Alexandria MurphyDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801.
Brenita JenkinsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801.
Ashlesha KadamDepartment of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157 USA.
Jianqiang ShaoCentral Microscopy Research Facility, University of Iowa, Iowa City, IA, 52242, USA.
Amber CrabtreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Pamela MartinDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208-3501, USA.
Chantell EvansDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, 27708, USA.
Mark A PhillipsDepartment of Integrative Biology, Oregon State University, Corvallis, OR, 97331, USA.ORCID 0000-0002-2319-7913
David HubertDepartment of Integrative Biology, Oregon State University, Corvallis, OR, 97331, USA.
Nelson WandiraDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
Okwute M OchayiDepartment of Human Physiology, Baze University, Abuja, Nigeria.
Dhanendra TomarDepartment of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157 USA.ORCID 0000-0002-3144-7257
Clintoria R WilliamsDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Jennifer GaddyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
Briar TomeauDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208-3501, USA.
LaCara BellDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208-3501, USA.
Taneisha GillyardDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208-3501, USA.
Markis' HamiltonDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208-3501, USA.
Vineeta SharmaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
Mohd Mabood KhanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Elma ZaganjorDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Olujimi A AjijolaUCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA.
Estevão ScudeseDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Tyne W Miller FlemingDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
André KinderArtur Sá Earp Neto University Center - UNIFASE-FMP, Petrópolis Medical School, Brazil.
Chandravanu DashDepartment of Microbiology, Immunology and Physiology, School of Medicine, Meharry Medical College, Nashville, TN, 37208, USA.ORCID 0000-0003-4466-8355
Anita M QuintanaDepartment of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, 79968, USA.ORCID 0000-0002-3596-1587
Bret C MobleyDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Julia D BerryDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Pooja JadiyaDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, NC.
Dao-Fu DaiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Annet KiraboDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Oleg KovtunDepartment of Chemistry, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0000-0001-6809-9332
Jenny C SchaferDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.
Sean SchafferDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.
Renata Oliveira PereiraDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, State College, PA 16801.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0000-0002-7730-952X

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah · 2017 to 2026
$48.2M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI William Thomas Harrison · 2021 to 2026
$24.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH, RODEN, DAN M · 2015 to 2019
$13.0M
BLRD VA I01 BX005352FIC NIH HHS D43 TW009744FIC NIH HHS R21 TW012635NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCI NIH HHS P30 CA068485NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS K23 HL156759NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL147818NHLBI NIH HHS R03 HL155041NHLBI NIH HHS R25 HL106365NHLBI NIH HHS U19 HL065962NIAID NIH HHS R01 AI136740NIAID NIH HHS R01 AI170228NIAID NIH HHS R25 AI164610NIA NIH HHS K01 AG062757NIA NIH HHS P30 AG072947NIA NIH HHS R00 AG065445NICHD NIH HHS R01 HD074711NICHD NIH HHS R01 HD090061NIDA NIH HHS R01 DA057204NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R00 DK120876NIDDK NIH HHS R01 DK112262NIDDK NIH HHS R01 DK133698NIDDK NIH HHS R21 DK119879NIDDK NIH HHS T32 DK007563NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD017985NIH HHS S10 OD025092NIMH NIH HHS S10 MH130456NINDS NIH HHS R01 NS032830
6 · The paper itself

Abstract

Due to aging, the efficiency of kidney function begins to decrease. Dysfunction in mitochondria and their cristae is a hallmark of aging. Therefore, age-related decline in kidney function could be attributed to changes in mitochondrial ultrastructure, increased reactive oxygen species, and alterations in metabolism and lipid composition. We sought to understand how mitochondrial ultrastructure is altered over time in tubular kidney cells. A serial block facing-scanning electron microscope and manual segmentation using the Amira software were employed to visualize murine kidney samples during the aging process at 3 months (young) and 2 years (old). We found that 2-year mitochondria are more fragmented with many uniquely shaped mitochondria observed across aging, concomitant with shifts in ROS, metabolomics, and lipid homeostasis. Furthermore, we demonstrate that the mitochondrial contact site and cristae organizing system (MICOS) complex is impaired in the kidney during aging. Disruption of the MICOS complex resulted in altered mitochondrial metabolic function and increased ROS levels. We found significant, detrimental structural changes in the mitochondria of aged kidney tubules, suggesting a potential mechanism underlying the increased frequency of kidney disease with aging. We hypothesize that disruption of the MICOS complex exacerbates mitochondrial dysfunction, creating a vicious cycle of mitochondrial degradation and oxidative stress, which impacts kidney health.

Indexed as

3DEMKidneyMetabolismMICOS complexMitochondria

Identifiers

PMID38915644
PMCPMC11195114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.