Evidence map›Paper›PMID 38915620›Full record

ArticlebioRxiv : the preprint server for biology2024

Combined effects of matrix stiffness and obesity-associated signaling directs progressive phenotype in PANC-1 pancreatic cancer cells

A E Jones, J F Netto, T L Foote, B N K Ruliffson, C F Whittington

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A E JonesWorcester Polytechnic Institute, Department of Biomedical Engineering.
J F NettoWorcester Polytechnic Institute, Department of Biomedical Engineering.
T L FooteWorcester Polytechnic Institute, Department of Biomedical Engineering.
B N K RuliffsonWorcester Polytechnic Institute, Department of Biomedical Engineering.
C F WhittingtonWorcester Polytechnic Institute, Department of Biomedical Engineering.ORCID 0000-0002-5821-4437

Funding

Using photopolymerizable collagen matrices to investigate how progressive stiffening alters lymphatic trafficking of cancer and immune cells in pancreatic ductal adenocarcinomaR03CA267449 · NCI · WORCESTER POLYTECHNIC INSTITUTE · PI WHITTINGTON, CATHERINE F · 2022 to 2023
$147k
NCI NIH HHS R03 CA267449
6 · The paper itself

Abstract

Obesity is a leading risk factor of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor disease prognosis and outcomes. Retrospective studies have identified this link, but interactions surrounding obesity and PDAC are still unclear. Research has shifted to contributions of fibrosis (desmoplasia) on malignancy, which involves increased deposition of collagens and other extracellular matrix (ECM) molecules and increased ECM crosslinking, all of which contribute to increased tissue stiffening. However, fibrotic stiffening is underrepresented as a model feature in current PDAC models. Fibrosis is shared between PDAC and obesity, and can be leveraged for

Indexed as

FibrosisIn vitro disease modelObesityPancreatic ductal adenocarcinomaTumor microenvironment

Identifiers

PMID38915620
PMCPMC11195209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.