ArticlebioRxiv : the preprint server for biology2025
A mechanism for telomere-specific telomere length regulation.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here we detail a mechanism of a telomere-specific set-length regulation that causes drastic differences in telomere length between individual telomeres in the same cell. Indeed, the results show that telomerase recruitment is modulated in
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