Evidence map›Paper›PMID 38915589›Full record

ArticlebioRxiv : the preprint server for biology2024

Mistranslating tRNA variants have anticodon- and sex-specific impacts on

Joshua R Isaacson, Matthew D Berg, Jessica Jagiello, William Yeung, Brendan Charles, Judit Villén, Christopher J Brandl, Amanda J Moehring

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Joshua R IsaacsonDepartment of Biology, Western University, N6A 5B7, London, Canada.ORCID 0000-0002-1323-0257
Matthew D BergDepartment of Genome Sciences, University of Washington, Seattle, Washington, 98195.ORCID 0000-0002-7924-9241
Jessica JagielloDepartment of Biology, Western University, N6A 5B7, London, Canada.
William YeungDepartment of Biology, Western University, N6A 5B7, London, Canada.
Brendan CharlesDepartment of Biology, Western University, N6A 5B7, London, Canada.
Judit VillénDepartment of Genome Sciences, University of Washington, Seattle, Washington, 98195.
Christopher J BrandlDepartment of Biochemistry, Western University, N6A 5B7, London, Canada.
Amanda J MoehringDepartment of Biology, Western University, N6A 5B7, London, Canada.

Funding

Emergent properties of signaling network degradation that mediate homeostatic failure during agingR01AG056359 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VILLEN, JUDIT · 2017 to 2021
$2.9M
Towards a comprehensive roadmap of cellular signaling.R35GM119536 · NIGMS · UNIVERSITY OF WASHINGTON · PI VILLEN, JUDIT · 2016 to 2020
$2.2M
The role of phosphorylation in the cellular organization of the proteomeR35GM152061 · NIGMS · UNIVERSITY OF WASHINGTON · PI Judit Villen · 2024 to 2026
$1.3M
Using metabolomics to identify mechanisms of natural variation in agingR56AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD, VILLEN, JUDIT · 2022 to 2022
$319k
NIA NIH HHS R01 AG056359NIA NIH HHS R56 AG049494NIGMS NIH HHS R35 GM119536NIGMS NIH HHS R35 GM152061
6 · The paper itself

Abstract

Transfer RNAs (tRNAs) are vital in determining the specificity of translation. Mutations in tRNA genes can result in the misincorporation of amino acids into nascent polypeptides in a process known as mistranslation. Since mistranslation has different impacts, depending on the type of amino acid substitution, our goal here was to compare the impact of different mistranslating tRNA

Indexed as

developmentDrosophila melanogasterlongevitymistranslationneurodegenerationproteostasistRNA

Identifiers

PMID38915589
PMCPMC11195196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.