Evidence map›Paper›PMID 38915588›Full record

ArticlebioRxiv : the preprint server for biology2024

Valine and Inflammation Drive Epilepsy in a Mouse Model of ECHS1 Deficiency.

Meghan M Eller, Aamir R Zuberi, Xiaorong Fu, Shawn C Burgess, Cathleen M Lutz, Rachel M Bailey

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meghan M EllerGraduate School of Biomedical Sciences, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75235.ORCID 0000-0002-7383-5549
Aamir R ZuberiThe Jackson Laboratory Center for Precision Genetics, The Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0003-0252-9760
Xiaorong FuCenter for Human Nutrition, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75235.ORCID 0000-0001-8042-4206
Shawn C BurgessCenter for Human Nutrition, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75235.ORCID 0000-0002-9586-5511
Cathleen M LutzThe Jackson Laboratory Center for Precision Genetics, The Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0003-2502-1900
Rachel M BaileyCenter for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75235.ORCID 0000-0002-5909-5548

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
The Jackson Laboratory Center for Precision GeneticsU54OD030187 · OD · JACKSON LABORATORY · PI Cathleen M Lutz · 2020 to 2026
$17.2M
The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI BURGESS, ROBERT W. · 2015 to 2019
$10.2M
Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2019 to 2023
$10.0M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Factors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8M
NCI NIH HHS P30 CA034196NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK078184NIH HHS U54 OD020351NIH HHS U54 OD030187
6 · The paper itself

Abstract

ECHS1 Deficiency (ECHS1D) is a rare and devastating pediatric disease that currently has no defined treatments. This disorder results from missense loss-of-function mutations in the

Indexed as

ECHS1EEGepilepsymetabolismmitochondrial disease

Identifiers

PMID38915588
PMCPMC11195255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.