ArticlebioRxiv : the preprint server for biology2024
Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics.
Dylan Steiner, Lila Sultan, Travis Sullivan, Hanqiao Liu, Sherry Zhang, Ashley LeClerc, Yuriy O Alekseyev, Gang Liu, Sarah A Mazzilli, Jiarui Zhang and 4 more
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
Dylan SteinerDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0003-1004-4368 Lila SultanDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Travis SullivanDepartment of Translational Research, Lahey Hospital and Medical Center, Burlington, MA, USA.ORCID 0000-0002-3395-0294 Hanqiao LiuDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Sherry ZhangDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Ashley LeClercBoston University Microarray and Sequencing Resource Core Facility, Boston, MA, USA.
Yuriy O AlekseyevDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0001-6105-8861 Gang LiuDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Sarah A MazzilliDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-9187-2722 Jiarui ZhangDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Kimberly Rieger-ChristDepartment of Translational Research, Lahey Hospital and Medical Center, Burlington, MA, USA.ORCID 0000-0002-8425-132X Eric J BurksDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-3122-2875 Jennifer BeaneDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-6699-2132 Marc E LenburgDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA, Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-5760-4708 Funding
Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung CancerU01CA196408 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABERLE, DENISE R., DUBINETT, STEVEN M. · 2015 to 2021
$7.1MIntegrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinomaR01CA275015 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Marc Elliott Lenburg, Fabien Maldonado · 2023 to 2026
$2.6MNCI NIH HHS R01 CA275015NCI NIH HHS U01 CA196408
6 · The paper itselfAbstract
Microscopic vascular invasion (VI) is predictive of recurrence and benefit from lobectomy in stage I lung adenocarcinoma (LUAD) but is difficult to assess in resection specimens and cannot be accurately predicted prior to surgery. Thus, new biomarkers are needed to identify this aggressive subset of stage I LUAD tumors. To assess molecular and microenvironment features associated with angioinvasive LUAD we profiled 162 resected stage I tumors with and without VI by RNA-seq and explored spatial patterns of gene expression in a subset of 15 samples by high-resolution spatial transcriptomics (stRNA-seq). Despite the small size of invaded blood vessels, we identified a gene expression signature of VI from the bulk RNA-seq discovery cohort (n=103) and found that it was associated with VI foci, desmoplastic stroma, and high-grade patterns in our stRNA-seq data. We observed a stronger association with high-grade patterns from VI
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PMID38915565
PMCPMC11195124
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