Evidence map›Paper›PMID 38915534›Full record

ArticlebioRxiv : the preprint server for biology2025

POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons.

Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia León, Elizabeth A McCarthy, Oline K Rønnekleiv and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rajae TalbiHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-7158-6246
Todd L StincicDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Kaitlin FerrariDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Choi Ji HaeDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Karol WalecDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Elizabeth MedveDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Achi GerutshangDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Silvia LeónHarvard Medical School, Boston, MA, USA.
Elizabeth A McCarthyHarvard Medical School, Boston, MA, USA.
Oline K RønnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Víctor M NavarroHarvard Medical School, Boston, MA, USA.

Funding

The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HADINE JOFFE · 2020 to 2026
$13.7M
Testosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI MCCARTNEY, CHRISTOPHER ROLLAND · 2014 to 2018
$8.6M
Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
Characterization of the role of the amygdala in reproductive functionR01HD099084 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2020 to 2024
$2.3M
Characterization of Kiss1 neurons as mediators of the reproductive regulation of energy balanceR01DK133760 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2022 to 2025
$2.2M
Dissecting the Role of Tachykinins in the Generation of GnRH PulsesR01HD090151 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2017 to 2021
$1.7M
Crosstalk between Estrogen and Metabolic Hormone Signaling in Kisspeptin NeuronsR56DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2020 to 2020
$262k
NIA NIH HHS U54 AG062322NICHD NIH HHS P50 HD028934NICHD NIH HHS R01 HD090151NICHD NIH HHS R01 HD099084NIDDK NIH HHS R01 DK068098NIDDK NIH HHS R01 DK133760NIDDK NIH HHS R56 DK068098
6 · The paper itself

Abstract

Inactivating mutations in the melanocortin 4 receptor (

Indexed as

EstradiolFertilityKiss1 neuronsMC4RObesityOvulationPOMC neurons

Identifiers

PMID38915534
PMCPMC11195098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.