Evidence map›Paper›PMID 38915533›Full record

ArticlebioRxiv : the preprint server for biology2024

Neuronal identity control at the resolution of a single transcription factor isoform.

Natalie Smolin, Mark Dombrovski, Bryce W Hina, Anthony Moreno-Sanchez, Ryan Gossart, Catherine R Carmona, Aadil Rehan, Roni H Hussein, Parmis Mirshahidi, Jessica Ausborn and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natalie SmolinSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.ORCID 0000-0002-3279-0858
Mark DombrovskiHoward Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA.ORCID 0000-0003-4710-2859
Bryce W HinaSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.ORCID 0000-0002-2685-8705
Anthony Moreno-SanchezDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA.ORCID 0000-0002-0174-0233
Ryan GossartBrandeis University, Department of Biology, Waltham, MA.
Catherine R CarmonaBrandeis University, Department of Biology, Waltham, MA.
Aadil RehanHoward Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA.
Roni H HusseinHoward Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA.
Parmis MirshahidiHoward Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA.
Jessica AusbornDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA.ORCID 0000-0003-4500-5131
Yerbol Z KurmangaliyevBrandeis University, Department of Biology, Waltham, MA.ORCID 0000-0003-4829-2025
Catherine R von ReynSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.ORCID 0000-0002-5753-2134

Funding

Neural algorithms underlying diversity in visual feature integrationR01NS118562 · NINDS · DREXEL UNIVERSITY · PI VON REYN, CATHERINE R · 2020 to 2024
$2.8M
NINDS NIH HHS R01 NS118562
6 · The paper itself

Abstract

The brain exhibits remarkable neuronal diversity which is critical for its functional integrity. From the sheer number of cell types emerging from extensive transcriptional, morphological, and connectome datasets, the question arises of how the brain is capable of generating so many unique identities. 'Terminal selectors' are transcription factors hypothesized to determine the final identity characteristics in post-mitotic cells. Which transcription factors function as terminal selectors and the level of control they exert over different terminal characteristics are not well defined. Here, we establish a novel role for the transcription factor

Indexed as

Cell IdentityDrosophila melanogasterElectrophysiologyNeurobiologyNeurodevelopmentscRNA-seqTerminal SelectorTranscription FactorsVisual Projection NeuronsVisual System

Identifiers

PMID38915533
PMCPMC11195191

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.