Evidence map›Paper›PMID 38915524›Full record

ArticlebioRxiv : the preprint server for biology2024

Synthetic genomes unveil the effects of synonymous recoding.

Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Akos NyergesDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1581-490X
Anush Chiappino-PepeDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Bogdan BudnikWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-3622-2003
Maximilien Baas-ThomasDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Regan FlynnDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Shirui YanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nili OstrovDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Min LiuGenScript USA Inc., Piscataway, NJ 08854, USA.
Meizhou WangGenScript USA Inc., Piscataway, NJ 08854, USA.
Qingmei ZhengGenScript USA Inc., Piscataway, NJ 08854, USA.
Fangxiang HuGenScript USA Inc., Piscataway, NJ 08854, USA.
Kangming ChenGenScript USA Inc., Piscataway, NJ 08854, USA.
Alexandra RudolphDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Dawn ChenDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8127-6014
Jenny AhnDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Owen SpencerDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Venkat AyalavarapuDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Angela TarverDOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Miranda Harmon-SmithDOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Matthew HamiltonDOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ian BlabyDOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-1631-3154
Yasuo YoshikuniDOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Behnoush HajianCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Adeline JinGenScript USA Inc., Piscataway, NJ 08854, USA.
Balint KintsesInstitute of Biochemistry, HUN-REN Biological Research Centre, Szeged, 6726, Hungary.
Monika SzamelInstitute of Biochemistry, HUN-REN Biological Research Centre, Szeged, 6726, Hungary.
Viktoria SeregiInstitute of Biochemistry, HUN-REN Biological Research Centre, Szeged, 6726, Hungary.
Yue ShenBGI Research, Shenzhen 518083, China.
Zilong LiGenScript USA Inc., Piscataway, NJ 08854, USA.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6232-9969

Funding

Development of a Gene-Transfer-Resistant and Biocontained Next-Generation Bacterial Host for Controlled Drug DeliveryK99EB035165 · NIBIB · HARVARD MEDICAL SCHOOL · PI NYERGES, AKOS · 2023 to 2024
$237k
NIBIB NIH HHS K99 EB035165
6 · The paper itself

Abstract

Engineering the genetic code of an organism provides the basis for (i) making any organism safely resistant to natural viruses and (ii) preventing genetic information flow into and out of genetically modified organisms while (iii) allowing the biosynthesis of genetically encoded unnatural polymers

Identifiers

PMID38915524
PMCPMC11195188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.