Evidence map›Paper›PMID 38915338›Full record

ArticleOpen forum infectious diseases2024

Factors Associated With the Discontinuation of Two Short-Course Tuberculosis Preventive Therapies in Programmatic Settings in the United States.

Michael Asare-Baah, LaTweika A T Salmon-Trejo, Thara Venkatappa, Richard S Garfein, Kaylynn Aiona, Michelle Haas, Marie Nancy Séraphin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael Asare-BaahDepartment of Epidemiology, University of Florida, Gainsville, Florida, USA.ORCID https://orcid.org/0000-0003-2409-2061
LaTweika A T Salmon-TrejoDepartment of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainsville, Florida, USA.
Thara VenkatappaDivision of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Richard S GarfeinHerbert Wertheim School of Public Health, University of California, San Diego, California, USA.
Kaylynn AionaPublic Health Institute at Denver Health, Denver, Colorado, USA.
Michelle HaasDivision of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado, USA.
Marie Nancy SéraphinEmerging Pathogens Institute, University of Florida, Gainsville, Florida, USA.

Funding

Linking within- and between-host dynamics in tracking recent Mycobacterium tuberculosis transmissionK01AI153544 · NIAID · UNIVERSITY OF FLORIDA · PI SERAPHIN, MARIE NANCY · 2021 to 2025
$652k
NIAID NIH HHS K01 AI153544
6 · The paper itself

Abstract

Background: The objective of this study was to investigate timing and risk factors for discontinuation of short-course tuberculosis preventive therapy (TPT) comparing directly observed 3-month isoniazid/rifapentine (3HP) vs self-administered 4-month rifampin (4R). Methods: This was a subanalysis of a 6-month health department cohort (2016-2017) of 993 latent tuberculosis infection (LTBI) patients initiating 3HP (20%) or 4R (80%). Time at risk of TPT discontinuation was compared across regimens. Risk factors were assessed using mixed-effects Cox models. Results: Short-course TPT discontinuation was higher with 4R (31% vs 14%; Conclusions: TPT discontinuation differed by regimen, with distinct risk factors. Addressing social determinants of health within TPT programs is critical to enhance completion rates and reduce TB disease risk in marginalized populations.

Indexed as

latent tuberculosis infectionpreventive therapyTB treatmenttreatment adherencetuberculosis

Identifiers

PMID38915338
PMCPMC11194754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.