Evidence map›Paper›PMID 38915214›Full record

ReviewChinese medical journal2025

Brain injury biomarkers and applications in neurological diseases.

Han Zhang, Jing Wang, Yang Qu, Yi Yang, Zhen-Ni Guo

Abstract readReview
In one paragraph

Review in Chinese medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Han ZhangStroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
Jing WangStroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yang QuStroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yi YangStroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
Zhen-Ni GuoStroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractNeurological diseases are a major health concern, and brain injury is a typical pathological process in various neurological disorders. Different biomarkers in the blood or the cerebrospinal fluid are associated with specific physiological and pathological processes. They are vital in identifying, diagnosing, and treating brain injuries. In this review, we described biomarkers for neuronal cell body injury (neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, αII-spectrin), axonal injury (neurofilament proteins, tau), astrocyte injury (S100β, glial fibrillary acidic protein), demyelination (myelin basic protein), autoantibodies, and other emerging biomarkers (extracellular vesicles, microRNAs). We aimed to summarize the applications of these biomarkers and their related interests and limits in the diagnosis and prognosis for neurological diseases, including traumatic brain injury, status epilepticus, stroke, Alzheimer's disease, and infection. In addition, a reasonable outlook for brain injury biomarkers as ideal detection tools for neurological diseases is presented.

Indexed as

BiomarkersBrain InjuriesNervous System DiseasesBrain Injuries, TraumaticGlial Fibrillary Acidic ProteinHumansMicroRNAsMyelin Basic ProteinNeurofilament ProteinsPhosphopyruvate HydrataseS100 Calcium Binding Protein beta Subunittau ProteinsUbiquitin ThiolesteraseBiomarkersGlial Fibrillary Acidic ProteinMicroRNAsMyelin Basic ProteinNeurofilament ProteinsPhosphopyruvate HydrataseS100 Calcium Binding Protein beta Subunittau ProteinsUbiquitin Thiolesterase

Identifiers

PMID38915214
PMCPMC11717530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.