Evidence map›Paper›PMID 38915069›Full record

ArticleBiological research2024

Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice.

Yatu Guo, Jiahui Qin, Ruiqiang Sun, Peng Hao, Zhixin Jiang, Yuchuan Wang, Zhiqi Gao, Huan Zhang, Keliang Xie, Wei Zhang

Abstract read
In one paragraph

Article in Biological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yatu Guo *Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China. yatu.guo@gmail.com.ORCID http://orcid.org/0000-0001-7486-0044
Jiahui Qin *Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China.
Ruiqiang Sun *Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Peng HaoTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Zhixin JiangTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Yuchuan WangTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Zhiqi GaoFenyang College of Shanxi Medical University, Shanxi, China.
Huan ZhangTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Keliang XieDepartment of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin, China.
Wei ZhangTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China. zhangwei3067@163.com.

Funding

Key project of Tianjin Eye Hospital YKZD2004National Natural Science Foundation of China 81300791Natural Science Foundation of Tianjin 18JCYBJC26500Open Funding of the Ophthalmology Research Institute at Nankai University NKYKK202308Tianjin Health Research Project TJWJ2021MS042Tianjin Health Research Project TJWJ2022XK037Tianjin Science and Technology support key Project 19YFZCSY00990
6 · The paper itself

Abstract

backgroundRetinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main cause of childhood blindness. Nowadays anti-VEGF and retinal photocoagulation are mainstream treatments for ROP, but they develop a variety of complications. Hydrogen (H

methodsIn this study, mice that were seven days old and either wild-type (WT) or Nrf2-deficient (Nrf2-/-) were exposed to 75% oxygen for 5 days and then returned to normal air conditions. Different stages of hydrogen gas (H

resultsOur results indicate that 3-4% H

conclusionsCollectively, our results indicate that H

Indexed as

Disease Models, AnimalHydrogenNeurogliaOxygenRetinal NeovascularizationRetinopathy of PrematurityAnimalsAnimals, NewbornImmunohistochemistryMiceMice, Inbred C57BLRegenerationRetinaRetinal VesselsHydrogenOxygenAngiogenesisDll4H2HIF-1αneovascularizationNotchNrf2OIRRetinal glia cellRevascularization

Identifiers

PMID38915069
PMCPMC11194953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.