Evidence map›Paper›PMID 38915064›Full record

ArticleJournal of neuroengineering and rehabilitation2024

Robot-aided assessment and associated brain lesions of impaired ankle proprioception in chronic stroke.

Qiyin Huang, Naveen Elangovan, Mingming Zhang, Ann Van de Winckel, Jürgen Konczak

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In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiyin HuangHuman Sensorimotor Control Laboratory, School of Kinesiology and Center for Clinical Movement Science, University of Minnesota, 1900 University Avenue SE, Minneapolis, MN, 55455, USA. huan1480@umn.edu.
Naveen ElangovanHuman Sensorimotor Control Laboratory, School of Kinesiology and Center for Clinical Movement Science, University of Minnesota, 1900 University Avenue SE, Minneapolis, MN, 55455, USA.
Mingming ZhangShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Ann Van de WinckelDivision of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota, Minneapolis, USA.
Jürgen KonczakHuman Sensorimotor Control Laboratory, School of Kinesiology and Center for Clinical Movement Science, University of Minnesota, 1900 University Avenue SE, Minneapolis, MN, 55455, USA.

Funding

National Natural Science Foundation of China 61903181Shenzhen Key Laboratory of Smart Healthcare Engineering ZDSYS20200811144003009
6 · The paper itself

Abstract

backgroundImpaired ankle proprioception strongly predicts balance dysfunction in chronic stroke. However, only sparse data on ankle position sense and no systematic data on ankle motion sense dysfunction in stroke are available. Moreover, the lesion sites underlying impaired ankle proprioception have not been comprehensively delineated. Using robotic technology, this study quantified ankle proprioceptive deficits post-stroke and determined the associated brain lesions.

methodsTwelve adults with chronic stroke and 13 neurotypical adults participated. A robot passively plantarflexed a participant's ankle to two distinct positions or at two distinct velocities. Participants subsequently indicated which of the two movements was further/faster. Based on the stimulus-response data, psychometric just-noticeable-difference (JND) thresholds and intervals of uncertainty (IU) were derived as measures on proprioceptive bias and precision. To determine group differences, Welch's t-test and the Wilcoxon-Mann-Whitney test were performed for the JND threshold and IU, respectively. Voxel-based lesion subtraction analysis identified the brain lesions associated with observed proprioceptive deficits in adults with stroke.

results83% of adults with stroke exhibited abnormalities in either position or motion sense, or both. JND and IU measures were significantly elevated compared to the control group (Position sense: + 77% in JND, + 148% in IU; Motion sense: +153% in JND, + 78% in IU). Adults with stroke with both impaired ankle position and motion sense had lesions in the parietal, frontal, and temporoparietal regions.

conclusionsThis is the first study to document the magnitude and frequency of ankle position and motion sense impairment in adults with chronic stroke. Proprioceptive dysfunction was characterized by elevated JND thresholds and increased uncertainty in perceiving ankle position/motion. Furthermore, the associated cortical lesions for impairment in both proprioceptive senses were largely overlapping.

Indexed as

AnkleProprioceptionRoboticsStrokeAdultAgedBrainChronic DiseaseFemaleHumansMaleMiddle AgedStroke RehabilitationMotion senseProprioceptionPsychometricsRoboticsStroke

Identifiers

PMID38915064
PMCPMC11194987

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