ArticleBMC geriatrics2024
Altered pupil light and darkness reflex and eye-blink responses in late-life depression.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Pupillary Light Reflex and Eye Movement Parameters as Objective Measures of Cognitive Decline in Older Adults: A Secondary Analysis of a Multimodal Public Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Trial-by-trial covariation of pupil dilation, microsaccades, and visual evoked potentials during saliency processing.iScience · 2026Article
- Transformer-based fusion model for mild depression recognition with EEG and pupil area signals.Medical & biological engineering & computing · 2025Article
- Disrupted microsaccade responses in late-life depression.Scientific reports · 2025Article
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- A novel approach to depression detection using POV glasses and machine learning for multimodal analysis.Frontiers in psychiatry · 2025Article
- Altered oculomotor signatures of emotional conflict and valence processing in late-life depression.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundLate-life depression (LLD) is a prevalent neuropsychiatric disorder in the older population. While LLD exhibits high mortality rates, depressive symptoms in older adults are often masked by physical health conditions. In younger adults, depression is associated with deficits in pupil light reflex and eye blink rate, suggesting the potential use of these responses as biomarkers for LLD.
methodsWe conducted a study using video-based eye-tracking to investigate pupil and blink responses in LLD patients (n = 25), older (OLD) healthy controls (n = 29), and younger (YOUNG) healthy controls (n = 25). The aim was to determine whether there were alterations in pupil and blink responses in LLD compared to both OLD and YOUNG groups.
resultsLLD patients displayed significantly higher blink rates and dampened pupil constriction responses compared to OLD and YOUNG controls. While tonic pupil size in YOUNG differed from that of OLD, LLD patients did not exhibit a significant difference compared to OLD and YOUNG controls. GDS-15 scores in older adults correlated with light and darkness reflex response variability and blink rates. PHQ-15 scores showed a correlation with blink rates, while MoCA scores correlated with tonic pupil sizes.
conclusionsThe findings demonstrate that LLD patients display altered pupil and blink behavior compared to OLD and YOUNG controls. These altered responses correlated differently with the severity of depressive, somatic, and cognitive symptoms, indicating their potential as objective biomarkers for LLD.
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