Evidence map›Paper›PMID 38914935›Full record

ArticleBMC infectious diseases2024

Hypertension and immune activation in antiretroviral therapy naïve people living with human immunodeficiency virus.

Tosi M Mwakyandile, Grace A Shayo, Philip G Sasi, Ferdinand M Mugusi, Godfrey Barabona, Takamasa Ueno, Eligius F Lyamuya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tosi M MwakyandileDepartment of Clinical Pharmacology, School of Biomedical Sciences, Campus College of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania. tosimwakys@gmail.com.
Grace A ShayoDepartment of Internal Medicine, School of Clinical Medicine, Campus College of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Philip G SasiDepartment of Clinical Pharmacology, School of Biomedical Sciences, Campus College of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Ferdinand M MugusiDepartment of Internal Medicine, School of Clinical Medicine, Campus College of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Godfrey BarabonaDivision of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Takamasa UenoDivision of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Eligius F LyamuyaCollaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.

Funding

To Reach the People: Transforming Health Professions Education in Tanzania (THET)R25TW011227 · FIC · MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS · PI KAAYA, EPHATA E, KWESIGABO, GIDEON PAUL · 2018 to 2022
$3.1M
Training Tanzanian Researchers for HIV/AIDS Implementation ScienceD43TW009775 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, Christopher Sudfeld · 2015 to 2026
$3.0M
FIC NIH HHS D43 TW009775FIC NIH HHS R25 TW011227Fogarty International Center (FIC) of the National Institutes of Health (NIH) 5D43 TW009775-03Fogarty International Center (FIC) of the National Institutes of Health (NIH) through the Transforming Health Education in Tanzania (THET) project 1R25TW011227-01JSPS Bilateral Open Partnership Joint Research Project JPJSBP120219933 and JPJSBP120239932JSPS Core-to-Core Program JPJSCCB20190009 and JPJSCCB20220010JSPS KAKENHI Grant-in-Aid for Scientific Research 21K19657, 22H03119, 22KK0148
6 · The paper itself

Abstract

backgroundThe pathogenesis of hypertension (HTN) in people living with HIV/AIDS (PLHIV) is complex and remains not fully understood. Chronic immune activation (IA) is postulated to be one of the culprits. This notion is derived from studies in HIV-uninfected populations and/or animals while data on HTN and how it relates to IA in PLHIV remains scarce. We determined the relationship between HTN and IA among antiretroviral therapy (ART) naïve PLHIV.

methodsWe analysed baseline data of 365 out of 430 clinical trial participants whose main aim was to investigate the effect of low-dose aspirin on HIV disease progression in PLHIV starting ART. Soluble CD14 (sCD14), T cells co-expressing CD38 and HLA-DR, and PD-1 were the IA and exhaustion markers, respectively studied and were analysed by flow cytometry. Mann-Whitney U-test was used for comparison of the markers by HTN status. A robust Poisson regression model was used to determine the predictors for HTN.

resultsA quarter of the 365 were hypertensive (25.3%, 95% CI 20.9-29.8%), and, had higher median (IQR) body mass index (kg/m

conclusionStudied markers of IA and exhaustion were higher in PLHIV with HTN than those without but were unpredictive of HTN. Larger multicentre studies with a wider range of markers are needed to confirm the role of IA in HIV-associated HTN.

Indexed as

HIV InfectionsHypertensionAdultBiomarkersFemaleHumansLipopolysaccharide ReceptorsMaleMiddle AgedBiomarkersLipopolysaccharide ReceptorsAntiretroviral therapyHIVHypertensionLymphocyte activationMonocyte activation

Identifiers

PMID38914935
PMCPMC11197211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.