Evidence map›Paper›PMID 38914919›Full record

ArticleInternational ophthalmology2024

Corneal innervation changes ın Alzheimer's: implications for sensory dysfunction.

Ali Osman Gundogan, Refik Oltulu, Selman Belviranli, Ali Tezcan, Mehmet Adam, Enver Mirza, Mustafa Altaş, Mehmet Okka

Abstract read
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In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali Osman GundoganDepartment of Ophthalmology, Yozgat City Hospital, Yozgat, Turkey. aogundogan@hotmail.com.ORCID http://orcid.org/0000-0001-7305-3443
Refik OltuluDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0003-2447-6524
Selman BelviranliDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0003-0272-7345
Ali TezcanDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0009-0000-4061-0020
Mehmet AdamDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0003-0552-5212
Enver MirzaDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0002-8847-5726
Mustafa AltaşDepartment of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0003-3011-1062
Mehmet OkkaDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0002-3908-1042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare, between Alzheimer's disease (AD) patients and healthy individuals, corneal subbasal nerve plexus (CSNP) parameters and corneal sensitivities.

methodsTwenty-two patients who were followed up with Alzheimer's disease (Alzheimer's group) and 18 age- and gender-matched healthy individuals (control group) were included in this cross-sectional study. CSNP parameters, including nerve fiber length (NFL), nerve fiber density (NFD), and nerve branch density (NBD), were evaluated using in vivo confocal microscopy. Corneal sensitivity was evaluated using a Cochet-Bonnet esthesiometer. The results were compared between the two groups.

resultsIn the Alzheimer's group, NFL was 12.2 (2.4) mm/mm

conclusionWe determined that, in AD, corneal sensitivity decreases significantly, in parallel with the decrease in corneal nerves. Changes in the corneal nerve plexus and a decrease in corneal sensitivity may be used in the early diagnosis and follow-up of AD. In addition, ocular surface problems secondary to these changes should also be kept in mind.

Indexed as

Alzheimer DiseaseCorneaMicroscopy, ConfocalNerve FibersAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedOphthalmic NerveSensation DisordersAlzheimer's diseaseCorneal sensitivityCorneal subbasal nerve plexusEsthesiometerIn vivo corneal confocal microscopy

Identifiers

PMID38914919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.