Evidence map›Paper›PMID 38914829›Full record

ArticleNature neuroscience2024

A high-density 1,024-channel probe for brain-wide recordings in non-human primates.

Yang Liu, Huilin Jia, Hongji Sun, Shengyi Jia, Ziqian Yang, Ao Li, Anqi Jiang, Yuji Naya, Cen Yang, Shengyuan Xue and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. An AI Agent for cell-type specific brain computer interfaces.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yang Liu *Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Huilin Jia *Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Hongji Sun *Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Shengyi JiaDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-2204-7841
Ziqian YangDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Ao LiSchool of Psychological and Cognitive Sciences, Peking University, Beijing, China.
Anqi JiangDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Yuji NayaSchool of Psychological and Cognitive Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-7386-6671
Cen YangSchool of Psychological and Cognitive Sciences, Peking University, Beijing, China.
Shengyuan XueSchool of Psychological and Cognitive Sciences, Peking University, Beijing, China.
Xiaojian LiCAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Bingyan ChenCAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Jingjun ZhuDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Chenghao ZhouDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Minning LiDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Xiaojie DuanDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China. xjduan@pku.edu.cn.ORCID http://orcid.org/0000-0001-7799-3897

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21972005National Natural Science Foundation of China (National Science Foundation of China) T2188101Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) JQ20008
6 · The paper itself

Abstract

Large-scale neural population recordings with single-cell resolution across the primate brain remain challenging. Here we introduce the Neuroscroll probe that isolates single neuronal activities simultaneously from 1,024 densely spaced channels that are flexibly distributed across the shank of the probe. The Neuroscroll probe length is easily tunable for individual probes from 10 mm to 90 mm, covering the brain size of non-human primates and humans, and the probes remain intact and functional after repeated bending deformations. The Neuroscroll probes provided reliable recordings from large neural populations with high chronic stability up to 105 weeks in rats. Recording with each Neuroscroll probe yielded hundreds of well-isolated single units simultaneously from multiple brain regions distributed across the entire depth of the rhesus macaque brain. With the thousand simultaneously recorded channels, unprecedented probe length, excellent mechanical stability and flexible recording site distribution, the Neuroscroll probes enable a wide range of new experimental paradigms in system neuroscience studies with great versatility.

Indexed as

BrainMacaca mulattaNeuronsAction PotentialsAnimalsElectrodes, ImplantedMaleRats

Identifiers

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.