ArticlePediatric research2025
Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Quantitative assessment of gastrointestinal motility in neonatal rats by real-time 3D photoacoustic imaging: A feasibility study.Photoacoustics · 2026Article
- Photoacoustic imaging of intestinal physiological biomarkers in infants and children.medRxiv : the preprint server for health sciences · 2026Article
- The role of abdominal ultrasound in surgical decision making for necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2026Review
- Imaging and Non-Imaging Approaches for the Diagnosis and Monitoring of Necrotizing Enterocolitis-What Lies Ahead?Children (Basel, Switzerland) · 2026Review
- [Recent advances in predicting the surgical timing for neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury.World journal of gastroenterology · 2025Article
- Photoacoustic imaging assessment of acute kidney injury associated with experimental necrotizing enterocolitis.bioRxiv : the preprint server for biology · 2025Article
- Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation.Photoacoustics · 2025Article
- Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS.Photoacoustics · 2025Article
- Changes in the Incidence and Severity of NEC over the Last Decade: A Single-Center Study.Journal of clinical medicine · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
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8 authors.
Funding
Abstract
backgroundNecrotizing enterocolitis (NEC) is an often-lethal disease of the premature infant intestinal tract, exacerbated by significant diagnostic difficulties. In NEC, the intestine exhibits hypoperfusion and dysmotility, contributing to disease pathogenesis. However, these features cannot be accurately and quantitively assessed with current imaging modalities. We have previously demonstrated the ability of photoacoustic imaging (PAI) to non-invasively assess intestinal tissue oxygenation and motility in a healthy neonatal rat model.
methodsIn this first-in-disease application, we evaluated NEC using PAI to assess intestinal health biomarkers in an experimental model of NEC. NEC was induced in neonatal rats from birth to 4-days. Healthy breastfed (BF) and NEC rat pups were imaged at 2- and 4-days.
resultsIntestinal tissue oxygen saturation was measured with PAI, and NEC pups showed significant decreases at 2- and 4-days. Ultrasound and PAI cine recordings were used to capture intestinal peristalsis and contrast agent transit within the intestine. Intestinal motility, assessed using computational intestinal deformation analysis, demonstrated significant reductions in both early and established NEC. NEC damage was confirmed with histology and dysmotility was confirmed by small intestinal transit assay.
conclusionThis preclinical study presents PAI as an emerging diagnostic imaging modality for intestinal disease assessment in premature infants. IMPACT: Necrotizing enterocolitis (NEC) is a devastating intestinal disease affecting premature infants with significant mortality. NEC presents significant clinical diagnostic difficulties, with limited diagnostic confidence complicating timely and effective interventional efforts. This study is an important foundational first-in-disease preclinical study that establishes the utility for PAI to detect changes in intestinal tissue oxygenation and intestinal motility with NEC disease induction and progression. This study demonstrates the feasibility and exceptional promise for the use of PAI to non-invasively assess oxygenation and motility in the healthy and diseased infant intestine.
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