Evidence map›Paper›PMID 38914718›Full record

ReviewNature genetics2024

A proposal for an inclusive working definition of genetic discrimination to promote a more coherent debate.

Beatrice Kaiser, Diya Uberoi, Maili C Raven-Adams, Katherine Cheung, Andreas Bruns, Subhashini Chandrasekharan, Margaret Otlowski, Anya E R Prince, Jane Tiller, Arzoo Ahmed and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Genomics and Discrimination in New Zealand Health and Life Insurance.Journal of the Royal Society of New Zealand · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Beatrice KaiserCentre of Genomics and Policy, McGill University, Montreal, Quebec, Canada.
Diya UberoiCentre of Genomics and Policy, McGill University, Montreal, Quebec, Canada.
Maili C Raven-AdamsGlobal Alliance for Genomics & Health, London, UK.
Katherine CheungCentre of Genomics and Policy, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0003-3529-4109
Andreas BrunsThe German Human Genome-Phenome Archive, University Hospital, Heidelberg, Germany.
Subhashini ChandrasekharanNational Institutes of Health, Bethesda, MD, USA.
Margaret OtlowskiCentre for Health, Law and Emerging Technologies, University of Oxford, Oxford, UK.
Anya E R PrinceThe University of Iowa College of Law, Iowa City, IA, USA.
Jane TillerMonash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-3906-6632
Arzoo AhmedGenomics England, London, UK.
Yvonne BombardInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9516-4539
Charles DuprasUniversity of Montreal, Montreal, Quebec, Canada.
Palmira Granados MorenoCentre of Genomics and Policy, McGill University, Montreal, Quebec, Canada.
Rosalyn RyanHealthfox US Inc., Chicago, IL, USA.
Augusto Valderrama-AguirreDepartment of Biological Sciences, Universidad de Los Andes, Bogotá DC, Colombia.ORCID http://orcid.org/0000-0002-5255-1440
Yann JolyCentre of Genomics and Policy, McGill University, Montreal, Quebec, Canada. yann.joly@mcgill.ca.ORCID http://orcid.org/0000-0002-8775-2322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic discrimination is an evolving phenomenon that impacts fundamental human rights such as dignity, justice and equity. Although, in the past, various definitions to better conceptualize genetic discrimination have been proposed, these have been unable to capture several key facets of the phenomenon. In this Perspective, we explore definitions of genetic discrimination across disciplines, consider criticisms of such definitions and show how other forms of discrimination and stigmatization can compound genetic discrimination in a way that affects individuals, groups and systems. We propose a nuanced and inclusive definition of genetic discrimination, which reflects its multifaceted impact that should remain relevant in the face of an evolving social context and advancing science. We argue that our definition should be adopted as a guiding academic framework to facilitate scientific and policy discussions about genetic discrimination and support the development of laws and industry policies seeking to address the phenomenon.

Indexed as

Human RightsGenetic PrivacyHumansPrejudiceSocial Discrimination

Identifiers

PMID38914718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.