Evidence map›Paper›PMID 38914703›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2024

Associations of combined genetic and lifestyle risks with hypertension and home hypertension.

Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Association of subjective and objective physical activity with home hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Article
  3. Article
  4. Current hypertension epidemiology and contemporary approaches using the "Real-World Evidence Cycle" framework.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  5. Review
  6. Article
  7. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  8. Review
  9. Could this be the first step towards a tailor-made lifestyle modification?Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Masato TakaseGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Takumi HirataTohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Naoki NakayaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tomohiro NakamuraTohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Mana KogureGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Rieko HatanakaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Kumi NakayaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Ippei ChibaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Ikumi KannoGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Kotaro NochiokaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Naho TsuchiyaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Akira NaritaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Hirohito MetokiGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Michihiro SatohGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Taku ObaraGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Mami IshikuroGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Hisashi OhsetoGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Akira UrunoTohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Tomoko KobayashiGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Eiichi N KodamaTohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Yohei HamanakaTohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Masatsugu OruiGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Soichi OgishimaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Satoshi NagaieGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Nobuo FuseGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Junichi SugawaraGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Shinichi KuriyamaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Gen TamiyaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Atsushi HozawaGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan. hozawa@megabank.tohoku.ac.jp.
Masayuki YamamotoGraduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
ToMMo investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.

Indexed as

HypertensionLife StyleAdultAgedAlcohol DrinkingBlood PressureBody Mass IndexCross-Sectional StudiesExerciseFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanMaleMiddle AgedHypertensionLifestyle risk reductionPolygenic risk score

Identifiers

PMID38914703
PMCPMC11298407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.