Trial reportScientific reports2024
Exploring botulinum toxin's impact on masseter hypertrophy: a randomized, triple-blinded clinical trial.
Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Efficacy of botulinum toxin type A in myogenic temporomandibulardisorders: a single arm, prospective, pilot study.Frontiers in rehabilitation sciences · 2025Trial
- Comparison of the effectiveness of botulinum toxin, dry needling, pharmacological treatment, and manual therapy for bruxism-induced myalgia: a prospective randomized study.Journal of oral & facial pain and headache · 2024Trial
- Non-Surgical Ear Rejuvenation Through Selective Neuromodulation with Onabotulinum and Abobotulinum Toxin-A.Toxins · 2026Article
- Observational
- Comment on Kang et al. The Effective Way of Botulinum Toxin Injection to Reduce Bite Force: Preliminary Study.Toxins · 2026Article
- Facial volume reduction and masticatory function after masseter botulinum toxin injection: a prospective study.BMC oral health · 2025Article
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- Effect of botulinum toxin type A on masticatory function and musculoskeletal structure in rabbits.Scientific reports · 2025Article
- Article
- The interconnection of oral and systemic health.Scientific reports · 2025Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to assess the effectiveness and functional adverse effects of a single and multiple injections of botulinum toxin A (BoNT-A) for masseter hypertrophy (MH). Twenty-six women complaining about lower third facial enlargement due to MH, received 75 U of BoNT-A (abobotulinum toxin) in each masseter muscles. After 3 months, patients were randomly assigned to receive a second treatment session of Saline Solution: (G1; n = 11) or BoNT-A: (G2; n = 12). Muscle thickness (ultrasound), electrical activity (electromyography; EMG), masticatory performance, and subjective perception of MH were evaluated. Follow-up was performed at 1, 3 and 6 months. Muscle thickness, EMG activity, and masticatory performance were analyzed using ANOVA two-way and Sidak test as post-hoc. Masticatory performance was analyzed by the Friedman's test and Mann-Whitney test. Regarding inter-groups comparisons, there was a significant decrease in the left masseter muscle thickness in the G2 group at the 6 month follow-up (p < 0.02). For EMG, significant differences were evident at the 6 month assessment, with higher masseter activity for G1 (p < 0.05). For masticatory performance, no significant differences were observed throughout the study (p > 0.05) and a higher improvement in subjective perception of MH was observed in the 1 month follow-up for G2 (p < 0.05). In conclusion, BoNT-A is effective for MH, however multiple injections cause functional adverse effects in masseter muscle.
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Registered trials
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