Evidence map›Paper›PMID 38914675›Full record

ArticleScientific reports2024

Prevalence of Helicobacter pylori resistance to certain antibiotics at An-Najah University Hospital: a cross-sectional study.

Qusay Abdoh, Mohammad Alnees, Lubna Kharraz, Khubaib Ayoub, Abdalaziz Darwish, Mahdi Awwad, Duha Najajra, Jana Khraim, Wafaa Awad, Aesha Sbaih and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Helicobacter pylori eradication in the face of escalating anti-microbial resistance: Geographic heterogeneity and emerging treatment strategies.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  3. Antimicrobial and Synergistic Activity of Metformin AgainstThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qusay Abdoh *Faculty of Medicine, An-Najah National University, Nablus, Palestine. Qusaygi@yahoo.com.ORCID 0009-0001-4356-8240
Mohammad Alnees *Faculty of Medicine, An-Najah National University, Nablus, Palestine. a2011z2012z2013@gmail.com.ORCID 0000-0002-5577-8499
Lubna KharrazFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Khubaib AyoubFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Abdalaziz DarwishFaculty of Medicine, An-Najah National University, Nablus, Palestine.ORCID 0000-0002-3231-3672
Mahdi AwwadFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Duha NajajraFaculty of Medicine, An-Najah National University, Nablus, Palestine.ORCID 0009-0007-3561-2380
Jana KhraimFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Wafaa AwadFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Aesha SbaihFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Safaa TurmanFaculty of Medicine, An-Najah National University, Nablus, Palestine.
Nizar Abu HamdehFaculty of Medicine, An-Najah National University, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance among bacteria is recognized as the primary factor contributing to the failure of treatment. In this research, our objective was to examine the prevalence of antibiotic resistance in H. pylori bacteria in Palestine. We enlisted 91 individuals suffering from dyspepsia, comprising 49 females and 42 males. These participants underwent esophagogastroduodenoscopy procedures with gastric biopsies. These biopsies were subsequently subjected to microbiological assessments and tested for their susceptibility to various antimicrobial drugs. Among the 91 patients, 38 (41.7%) exhibited the presence of H. pylori. Notably, Ciprofloxacin displayed the highest efficacy against H. pylori, followed by Levofloxacin, Moxifloxacin, and Amoxicillin, with resistance rates of 0%, 0%, 2.6%, and 18.4%, respectively. On the contrary, Metronidazole and Clarithromycin demonstrated the lowest effectiveness, with resistance percentages of 100% and 47.4%, respectively. The outcomes of this investigation emphasize that H. pylori strains within the Palestinian patient group exhibit substantial resistance to conventional first-line antibiotics like clarithromycin and metronidazole. However, alternative agents such as fluoroquinolones and amoxicillin remain efficacious choices. Consequently, we recommend favoring quinolone-based treatment regimens for H. pylori infections and adopting a more judicious approach to antibiotic usage among the Palestinian population.

Indexed as

Anti-Bacterial AgentsHelicobacter InfectionsHelicobacter pyloriAdultAmoxicillinClarithromycinCross-Sectional StudiesDrug Resistance, BacterialFemaleHospitals, UniversityHumansLevofloxacinMaleMetronidazoleMicrobial Sensitivity TestsMiddle AgedAmoxicillinAnti-Bacterial AgentsClarithromycinLevofloxacinMetronidazoleAntibiotic resistanceAntimicrobial susceptibility testingCiprofloxacinHelicobacter pylori

Identifiers

PMID38914675
PMCPMC11196700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.