Evidence map›Paper›PMID 38914635›Full record

ArticleScientific reports2024

Circulating C-reactive protein levels as a prognostic biomarker in breast cancer across body mass index groups.

J B Holm, E Baggesen, D Cronin-Fenton, J Frystyk, J M Bruun, P Christiansen, S Borgquist

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Article
  9. HbABMC cancer · 2025
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J B HolmDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark. jonasbuskholm@oncology.au.dk.ORCID http://orcid.org/0009-0009-6004-0104
E BaggesenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
D Cronin-FentonDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9738-2284
J FrystykDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.ORCID http://orcid.org/0000-0002-5379-0961
J M BruunDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9937-5467
P ChristiansenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2748-9240
S BorgquistDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-7938-8893

Funding

Kræftens Bekæmpelse R288-A16168Kræftens Bekæmpelse R327-A19070Novo Nordisk Fonden NNF20OC0065928
6 · The paper itself

Abstract

Obesity and systemic inflammation are associated with breast cancer (BC) outcomes. Systemic inflammation is increased in obesity. We examined the association between C-reactive protein (CRP) and disease-free survival (DFS) and overall survival (OS) overall, and according to body mass index (BMI). We assembled a cohort of women with BC (stage I-III) seen at Aarhus University Hospital between 2010 and 2020 who donated blood at BC diagnosis (N = 2673). CRP levels were measured and divided into quartiles. We followed patients from surgery to recurrence, contralateral BC, other malignancy, death, emigration, or end-of-follow-up. We used Cox regression to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs) to compare outcomes across CRP quartiles, overall and stratified by BMI (normal-weight (18.5 ≤ BMI < 25 kg/m

Indexed as

Biomarkers, TumorBody Mass IndexBreast NeoplasmsC-Reactive ProteinObesityAdultAgedDisease-Free SurvivalFemaleHumansInflammationMiddle AgedNeoplasm Recurrence, LocalPrognosisBiomarkers, TumorC-Reactive ProteinBody mass indexBreast cancerC-reactive proteinInflammationObesityPrognosis

Identifiers

PMID38914635
PMCPMC11196728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.