Evidence map›Paper›PMID 38914593›Full record

ArticleScientific reports2024

Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells.

Kota Fujiki, K Tanabe, S Suzuki, A Mochizuki, M Mochizuki-Kashio, T Sugaya, T Mizoguchi, M Itoh, A Nakamura-Ishizu, H Inamura and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kota FujikiDepartment of Hygiene and Public Health, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. bunnsidairoku@gmail.com.
K TanabeInstitute for Comprehensive Medical Sciences, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
S SuzukiGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
A MochizukiDepartment of Bio-Medical Engineering, School of Engineering, Tokai University, Kanagawa, 259-1143, Japan.
M Mochizuki-KashioDepartment of Microanatomy and Development Biology, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
T SugayaDivision of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
T MizoguchiGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
M ItohGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
A Nakamura-IshizuDepartment of Microanatomy and Development Biology, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
H InamuraDepartment of Hygiene and Public Health, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
M MatsuokaDepartment of Hygiene and Public Health, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Funding

Japan Society for the Promotion of Science 19K07052Japan Society for the Promotion of Science 19K10582
6 · The paper itself

Abstract

We have reported that an environmental pollutant, cadmium, promotes cell death in the human renal tubular cells (RTCs) through hyperactivation of a serine/threonine kinase Akt. However, the molecular mechanisms downstream of Akt in this process have not been elucidated. Cadmium has a potential to accumulate misfolded proteins, and proteotoxicity is involved in cadmium toxicity. To clear the roles of Akt in cadmium exposure-induced RTCs death, we investigated the possibility that Akt could regulate proteotoxicity through autophagy in cadmium chloride (CdCl

Indexed as

AutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCadmiumProto-Oncogene Proteins c-aktCadmium ChlorideCell LineHeterocyclic Compounds, 3-RingHumansKidney TubulesKidney Tubules, ProximalPhosphorylationBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCadmiumCadmium ChlorideHeterocyclic Compounds, 3-RingMK 2206Proto-Oncogene Proteins c-aktTFE3 protein, humanTFEB protein, humanAggresomeAktCadmiumCell deathRenal proximal tubular cells

Identifiers

PMID38914593
PMCPMC11196260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.