Evidence map›Paper›PMID 38914568›Full record

ArticleNature communications2024

Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics.

Pietro Belleri, Judith Pons I Tarrés, Iain McCulloch, Paul W M Blom, Zsolt M Kovács-Vajna, Paschalis Gkoupidenis, Fabrizio Torricelli

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  11. Article
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  14. Performance-Recoverable Closed-Loop Neuroprosthetic System.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  15. Biohybrid Computing with Proteinoids and Algae.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Article
  17. Bifurcation and Frequency Properties of S-Type Neuronic Oscillators.The journal of physical chemistry letters · 2025
    Review
  18. Review
  19. Bio-Inspired Neuromorphic Sensory Systems from Intelligent Perception to Nervetronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pietro BelleriDepartment of Information Engineering, University of Brescia, via Branze 38, 25123, Brescia, Italy.ORCID http://orcid.org/0000-0002-3657-1185
Judith Pons I TarrésMax Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.ORCID http://orcid.org/0009-0005-8560-7729
Iain McCullochDepartment of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, UK.ORCID http://orcid.org/0000-0002-6340-7217
Paul W M BlomMax Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.ORCID http://orcid.org/0000-0002-6474-9497
Zsolt M Kovács-VajnaDepartment of Information Engineering, University of Brescia, via Branze 38, 25123, Brescia, Italy.ORCID http://orcid.org/0000-0003-4460-7683
Paschalis GkoupidenisMax Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany. gkoupidenis@mpip-mainz.mpg.de.ORCID http://orcid.org/0000-0002-0139-0851
Fabrizio TorricelliDepartment of Information Engineering, University of Brescia, via Branze 38, 25123, Brescia, Italy. fabrizio.torricelli@unibs.it.ORCID http://orcid.org/0000-0002-7932-0677

Funding

Carl-Zeiss-Stiftung (Carl Zeiss Foundation) Emergent AI Center, JGU Mainz
6 · The paper itself

Abstract

Organic artificial neurons operating in liquid environments are crucial components in neuromorphic bioelectronics. However, the current understanding of these neurons is limited, hindering their rational design and development for realistic neuronal emulation in biological settings. Here we combine experiments, numerical non-linear simulations, and analytical tools to unravel the operation of organic artificial neurons. This comprehensive approach elucidates a broad spectrum of biorealistic behaviors, including firing properties, excitability, wetware operation, and biohybrid integration. The non-linear simulations are grounded in a physics-based framework, accounting for ion type and ion concentration in the electrolytic medium, organic mixed ionic-electronic parameters, and biomembrane features. The derived analytical expressions link the neurons spiking features with material and physical parameters, bridging closer the domains of artificial neurons and neuroscience. This work provides streamlined and transferable guidelines for the design, development, engineering, and optimization of organic artificial neurons, advancing next generation neuronal networks, neuromorphic electronics, and bioelectronics.

Indexed as

ElectronicsModels, NeurologicalNeuronsAction PotentialsNeural Networks, Computer

Identifiers

PMID38914568
PMCPMC11196688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.