Evidence map›Paper›PMID 38913419›Full record

Trial reportBJS open2024

Feasibility of robotic-assisted surgery in advanced rectal cancer: a multicentre prospective phase II study (VITRUVIANO trial).

Atsushi Hamabe, Ichiro Takemasa, Masanori Kotake, Daisuke Nakano, Suguru Hasegawa, Akio Shiomi, Masakatsu Numata, Kazuhiro Sakamoto, Kei Kimura, Tsunekazu Hanai and 13 more

Abstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Essential Updates 2024-2026: Advances in Colorectal Cancer Surgery.Annals of gastroenterological surgery · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Atsushi HamabeDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Ichiro TakemasaDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Masanori KotakeDepartment of Surgery, Koseiren Takaoka Hospital, Takaoka, Japan.
Daisuke NakanoDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Suguru HasegawaDepartment of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.ORCID 0000-0002-8641-8197
Akio ShiomiDivision of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.ORCID 0000-0001-5657-8686
Masakatsu NumataDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Kazuhiro SakamotoDepartment of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Kei KimuraDivision of Lower GI, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.ORCID 0000-0002-4646-667X
Tsunekazu HanaiDepartment of Surgery, Fujita Health University, School of Medicine, Toyoake, Japan.
Takeshi NaitohDepartment of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Yosuke FukunagaGastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID 0000-0002-6397-0907
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-7885-2276
Jun WatanabeDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.ORCID 0000-0002-7187-3664
Junichiro KawamuraDepartment of Surgery, Kindai University Faculty of Medicine, Osakasayama, Japan.ORCID 0000-0001-5404-5317
Mayumi OzawaDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Koji OkabayashiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0001-8554-1137
Shuichiro MatobaDepartment of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan.
Yoshinao TakanoDepartment of Surgery, Southern TOHOKU Research Institute for Neuroscience, Southern TOHOKU General Hospital, Koriyama, Japan.
Mamoru UemuraDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-3366-3826
Yoshiharu SakaiDepartment of Surgery, Osaka Red-Cross Hospital, Osaka, Japan.
Masahiko WatanabeDepartment of Surgery, Kitasato University Kitasato Institute Hospital, Tokyo  Japan.

Funding

Intuitive Surgical Sàrl
6 · The paper itself

Abstract

backgroundThe potential benefits of robotic-assisted compared with laparoscopic surgery for locally advanced cancer have not been sufficiently proven by prospective studies. One factor is speculated to be the lack of strict surgeon criteria. The aim of this study was to assess outcomes for robotic surgery in patients with locally advanced rectal cancer with strict surgeon experience criteria.

methodsA criterion was set requiring surgeons to have performed more than 40 robotically assisted operations for rectal cancer. Between March 2020 and May 2022, patients with rectal cancer (distance from the anal verge of 12 cm or less, cT2-T4a, cN0-N3, cM0, or cT1-T4a, cN1-N3, cM0) were registered. The primary endpoint was the rate positive circumferential resection margin (CRM) from the pathological specimen. Secondary endpoints were surgical outcomes, pathological results, postoperative complications, and longterm outcomes.

resultsOf the 321 registered patients, 303 were analysed, excluding 18 that were ineligible. At diagnosis: stage I (n = 68), stage II (n = 84) and stage III (n = 151). Neoadjuvant therapy was used in 56 patients. There were no conversions to open surgery. The median console time to rectal resection was 170 min, and the median blood loss was 5 ml. Fourteen patients had a positive CRM (4.6%). Grade III-IV postoperative complications were observed in 13 patients (4.3%).

conclusionRobotic-assisted surgery is feasible for locally advanced rectal cancer when strict surgeon criteria are used.

Indexed as

Feasibility StudiesRectal NeoplasmsRobotic Surgical ProceduresAdultAgedAged, 80 and overFemaleHumansLaparoscopyMaleMargins of ExcisionMiddle AgedNeoadjuvant TherapyNeoplasm StagingOperative TimePostoperative Complications

Identifiers

PMID38913419
PMCPMC11195309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.