Evidence map›Paper›PMID 38913281›Full record

ArticleFunctional & integrative genomics2024

RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression.

Nan Wang, Xiaodan Miao, Wenxin Lu, Yang Ji, Yuxin Zheng, Di Meng, Hui Liu, Chenxi Xiang

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Article in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nan WangDepartment of Pathology, Xuzhou Medical University, Xuzhou, China.
Xiaodan MiaoDepartment of Pathology, Xuzhou Medical University, Xuzhou, China.
Wenxin LuDepartment of Pathology, Xuzhou Medical University, Xuzhou, China.
Yang JiDepartment of Pathology, Xuzhou Medical University, Xuzhou, China.
Yuxin ZhengDepartment of Pathology, Xuzhou Medical University, Xuzhou, China.
Di MengDepartment of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Hui LiuDepartment of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Chenxi XiangDepartment of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. hejubu@foxmail.com.

Funding

National Natural Science Foundation of China No. 82003165
6 · The paper itself

Abstract

Breast cancer severely affects women health. 70% of breast cancer are estrogen receptor positive. Breast cancer stem cells are a group of tumor with plasticity, causing tumor relapse and metastasis. RUNX3 is a tumor suppressor frequently inactivated in estrogen receptor positive breast cancer. However, the mechanism of how RUNX3 is involved in the regualation of cancer stem cell traits in estrogen receptor positive breast cancer remains elusive. In this study, we utilized cut-tag assay to investigate the binding profile RUNX3 in BT474 and T47D cell, and confirmed EXOSC4 as the bona-fide target of RUNX3; RUNX3 could bind to the promoter are of EXOSC4 to suppress its expression. Furthermore, EXOSC4 could increase the colony formation, cell invasion and mammosphere formation ability of breast cancer cells and upregulate the the expression of SOX2 and ALDH1. Consistent with these findings, EXOSC4 was associated with poorer survival for Luminal B/Her2 breast cancer patiens. At last, we confirmed that EXOSC4 mediated the tumor suppressive role of RUNX3 in breast cancer cells. In conclusion, we demonstrate that RUNX3 directly binds to the promoter region of EXOSC4, leading to the suppression of EXOSC4 expression and exerting a tumor-suppressive effect in estrogen receptor postivive breast cancer cells.

Indexed as

Breast NeoplasmsCore Binding Factor Alpha 3 SubunitPromoter Regions, GeneticAldehyde Dehydrogenase 1 FamilyCell Line, TumorExosome Multienzyme Ribonuclease ComplexFemaleGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsRetinal DehydrogenaseRNA-Binding ProteinsSOXB1 Transcription FactorsAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanCore Binding Factor Alpha 3 SubunitEXOSC4 protein, humanExosome Multienzyme Ribonuclease ComplexRetinal DehydrogenaseRNA-Binding ProteinsRunx3 protein, humanSOX2 protein, humanSOXB1 Transcription FactorsBreast cancerCancer stem cellsEstrogen receptorEXOSC4RUNX3

Identifiers

PMID38913281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.