Citral and triclosan synergistically silence quorum sensing and potentiate antivirulence response in Pseudomonas aeruginosa.

Jatin Chadha, Prerna Ahuja, Umang Mudgil, Lavanya Khullar, Kusum Harjai

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Article in Archives of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

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36citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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36 citing papers in PubMed.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jatin Chadha *Department of Microbiology, Panjab University, Chandigarh, India.

Prerna Ahuja *Department of Microbiology, Panjab University, Chandigarh, India.

Umang MudgilDepartment of Microbiology, Panjab University, Chandigarh, India.

Lavanya KhullarDepartment of Microbiology, Panjab University, Chandigarh, India.

Kusum HarjaiDepartment of Microbiology, Panjab University, Chandigarh, India. kusumharjai@pu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the ESKAPE pathogens, Pseudomonas aeruginosa is an extensively notorious superbug that causes difficult-to-treat infections. Since quorum sensing (QS) directly promotes pseudomonal virulence, targeting QS circuits is a promising approach for disarming phenotypic virulence. Hence, this study scrutinizes the anti-QS, antivirulence, and anti-biofilm potential of citral (CiT; phytochemical) and triclosan (TcN; disinfectant), alone and in combination, against P. aeruginosa PAO1/PA14. The findings confirmed synergism between CiT and TcN and revealed their quorum quenching (QQ) potential. At sub-inhibitory levels, CiT-TcN combination significantly impeded pyocyanin, total bacterial protease, hemolysin, and pyochelin production alongside inhibiting biofilm formation in P. aeruginosa. Moreover, the QQ and antivirulence potential of CiT and TcN was positively correlated by molecular docking studies that predicted strong associations of the drugs with QS receptors of P. aeruginosa. Collectively, the study identifies CiT-TcN as an effective drug combination that harbors QQ, antivirulence, and anti-biofilm prospects against P. aeruginosa.

Indexed as

Acyclic MonoterpenesAnti-Bacterial AgentsBiofilmsDrug SynergismMolecular Docking SimulationPseudomonas aeruginosaQuorum SensingTriclosanBacterial ProteinsPyocyanineVirulenceAcyclic MonoterpenesAnti-Bacterial AgentsBacterial ProteinscitralPyocyanineTriclosanBiofilm inhibitionCitralPseudomonas aeruginosaQuorum quenchingTriclosanVirulence

Identifiers

PMID38913239

DOI10.1038/nprot.2007.521

What OpenQuestion holds

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.